颈部淋巴结内注射变应原特异性免疫治疗儿童变应性鼻炎的临床研究

目的 探究颈部淋巴结内注射变应原特异性免疫治疗(ICLIT)儿童变应性鼻炎(AR)的疗效及安全性.方法 回顾性研究24例儿童AR行ICLIT治疗的临床资料,观察患儿基线水平及治疗后1年鼻部症状评分、眼部症状评分、药物评分以及治疗过程中发生不良反应情况,探讨其疗效及安全性.结果 24例AR患儿基线水平鼻部总症状评分为(6...

Clinical study of cervical intralymphatic immunotherapy for allergic rhinitis in children

Objective To investigate the efficacy and safety of cervical intralymphatic immunotherapy (CILIT) in children with allergic rhinitis (AR).Methods Clinical data of 24 AR children treated with CILIT were studied retrospectively. The nasal symptom score, ocular symptom score, drug score at baseline and one year after CILIT, as well as adverse reactions during treatment were observed and recorded to explore the efficacy and safety of CILIT.Results The total nasal symptom score, ocular symptom score, and drug score at the baseline were (6.00±2.13), (3.29±2.12) and (2.67±1.17) respectively, while those at one year after CILIT were (2.96±2.48), (1.88±1.26), and (1.25±1.19) The differences between the baseline levels and those at one year after CILIT were all statistically significant (all P<0.01). The total effective rate at one year after CILIT was 75%. During the treatment and follow-up period, only 2 of the 24 children had light local adverse reactions without systemic adverse reactions.Conclusion With good effect and safety, CILIT can significantly alleviate the allergic symptoms of AR in children and greatly shorten the immunotherapy cycle.