系统化管理干预辅助补肾活血法用于黄体功能不全性复发性流产的效果

目的探讨系统化管理F预辅助补肾活血法用于黄体功能不全(LPD)性复发性流产的效果。方法选取2016年1月至2017年1月浙江省丽水市中医院妇产科门诊治疗的IPD性复发性流产患者84例,采用随机数字表法分为联合组与对照组,每组各42例。对照组患者予补肾活血法治疗,联合组患者在对照组基础上加系统化管理干预,两组患者疗程为3个月经周期。比较两组患者治疗前后性激素[卵泡刺激素(FSH)和雌二醇(E)]水平和子宫内膜厚度的变化,并比较其临床疗效及2年内成功分娩率。结果治疗3个月经周期后,两组患者血清FSH和E.水平明显上升,子宫内膜厚度明显增厚(P<0.05或P<0.01),且联合组患者变化幅度与对照组比较更明显(P<0.05);同时联合组患者临床总有效率(95.24% )明显高于对照组(80.95%) ,差异有统计学意义(x24.090,P<0.05)。随访2年,联合组患者的分娩成功率为47.62%(20142).明显高于对照组的2.196/1142)(x=4.141,P<0.05)。结论系统化管理F预辅助补肾活血法治疗LPD性复发性流产患者的疗效确切,可增加子宫内膜厚度,使成功分娩率明显提高,其作用机制与促进性激素FSH和E的分泌密切相关。

Effect of systematic management intervention assisted by tonifying kidney and activating blood circulation method on recurrent abortion with luted phase defect

Objetive To investigate the fet of sytematie managrment intevention asistedd by tonifying kidney and activating blood circulation method on reeument abortion with luted phase defect (LPD). Methods A total of 84 patients with recurrent abrtion with IPD treated in the clinie of emecologyo and obstetris o Lishui Hospital of Traditional Chinese Medicine in Zhejiang Prorince from January 2016 to January 2017 were selected, and they were divided into the combined goup (=42) and the control group (n=42) acconding to the random number table metho[J]. Patients in the control group were treated with tonifig kidney and activating blood circulation method, while patients in the coabined group were treated with systematie manapenent interention o the basis of the control group, and the two groups of patients were teated for 3 mentual eyeles coninuouly The lerel of sex bormones Fllele simulating hormone (FSH) and estndiol (EM] and endometrial thicknese changes before and after treatment were observed, and the elinical efcaey and sccessful delivery mate within 2 yeans were compared between the two groups of pabeats. Results After 3 menstrual cyeles, the senum FSH and E levels of the two groups were signifcantly increased, and the endometrial thicknes in cresed sgifcanl (P<005 or Pc001). Meanwhile, the change range of patients in the conmbined group was more obri-ou than that in the control gmup (P<005). At the same time, the total elinical efective rale in patients of the combined goup was 95_24%, which was sipuificantly higher than 80.95% of the contmol goup, with satistally signifcant diler ence between the two groups (x²=4.090, P<0.05). Aiter 2 yeans of fllowou, the delivery success ate of patients in the combined group was 47.62% (2042), which wa sgificanl bigher than that in the control goup 26.19% 1142), with stistically sigifcant dfference between the two goups (x¹=4.141, P<0.05). Condusion Systematie management inter-vention ssisted by toifying kidney and activating blood eireulation method has defirite thenapeutie eficary on patients with recurrent abortion with IPD, which can inerease endometrial thicekness and boost the sucoessful delivery rate olbwi-oealy. Ihs mecharism is closely related to promoting the secretion of sex hrrmones of FSH and E