| 四苯基卟啉锰配合物与牛血清白蛋白相互作用的研究 |
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| 引用本文： | 张红霞,刘建业,李青山. 四苯基卟啉锰配合物与牛血清白蛋白相互作用的研究[J]. 山西医科大学学报, 2001, 32(2): 138-140 |
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| 作者姓名： | 张红霞 刘建业 李青山 |
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| 作者单位： | 山西医科大学药学院药剂学教研室, |
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| 基金项目： | 国家自然科学基金资助项目(39900185) |
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| 摘 要： | 用分光光度法研究了四苯基卟啉锰配合物（Mn^3 TPPCl)与牛血清白蛋白（BSA）之间的相互作用，测定了二者相互作用的平衡常数和热力学参数，发现二者之间可形成1：1的配合物，BSA存在一个强结合位。在它们的相互作用过程中发生氧化还原反应，一个电子上BSA转移至MnTPPCl。
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| 关 键 词： | 四苯基卟啉锰 血清白蛋白 牛 分光光度法 配合物 药物相互作用 |
| 文章编号： | 1007-6611(2001)02-0138-03 |
| 修稿时间： | 2000-07-04 |
Interaction between Mn~(3 ) tetraphenylpor phyrin and bovine serum albumin |
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| ZHANG Hong-xia,LIU Jian-ye,LI Qing-shan. Interaction between Mn~(3 ) tetraphenylpor phyrin and bovine serum albumin[J]. Journal of Shanxi Medical University, 2001, 32(2): 138-140 |
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| Authors: | ZHANG Hong-xia LIU Jian-ye LI Qing-shan |
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| Abstract: | The interaction between Mn3+ tetraphenylporphyrin (MnTPPC1) and bovine serum albumin(BSA) was studied in DMF using spectral technique. The equilibrium constants, the enthalpies, and the entropies of the system were measured. The results suggest that a 1:1 adduct is formed during the interaction between MnTPPCI and BSA. There is one specific binding site in BSA molecule, which is connected with MnTPPCI. During the interaction, a redox reaction occurs and one electron is transferred from BSA to MnTPPC1. |
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| Keywords: | Mn tetraphenylporphyrin serum alb umin bovine spectrophotometry |
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