溴隐亭在120例泌乳素水平正常的不孕症患者促排卵治疗中的辅助作用观察

目的:探讨溴隐亭在泌乳素水平正常的不孕症患者促排卵治疗中的辅助作用。方法:不孕症患者120例,以随机抽样法分为对照组(60例)与治疗组(60例)。对照组于月经周期第5 d开始口服枸橼酸氯米酚50 mg.d-1,共5 d;月经周期第9 d开始B超监测卵泡发育情况并测量子宫内膜厚度,当优势卵泡直径达到18 mm时,加用人绒毛膜促性腺激素10 000 IU诱发排卵。治疗组除上述治疗外于月经周期第1 d开始口服溴隐亭1.25 mg.d-1,若妊娠则停药,未妊娠则连续服用3个月。结果:对照组排卵期子宫内膜厚度平均为(7.3±1.7)mm,治疗组为(10.3±2.1)mm,差异有统计学意义(P<0.05)。对照组第1、2、3个月获得妊娠分别为6、4、4例,妊娠率为23%(14/60),先兆流产发生率为42%(6/14);治疗组第1、2、3个月获得妊娠分别为14、10、6例,妊娠率为50%(30/60),先兆流产发生率为26%(8/30),差异有统计学意义(P<0.05)。结论:溴隐亭联合枸橼酸氯米酚用于泌乳素水平正常的不孕症患者,可提高其妊娠率,疗效显著。

Adjuvant Efficacy of Bromocriptine in Ovulation Induction Treatment for Patients with Infertility and Normal Prolactin Level:Analysis of 120 Cases

OBJECTIVE: To investigate the adjuvant action of bromocriptine in ovulation induction therapy for patients with infertility and normal prolactin level.METHODS: 120 patients with infertility were randomly divided into control group and treatment group of 60 each.In the control group,oral clomifene citrate tablets(50 mg·d-1) were administered on day 5 of menstrual cycle for 5 days,with follicular development tested by B-ultrasound and endometrial thickness measured on day 9,and HCG(human chorionic gonadotrophin) at 10 000 IU were administered to induce ovulation when the dominant follicle diameter reached 18 mm;the treatment group received add-on oral bromocriptine 1.25 mg·d-1 on day 1 for 3 months but which was discontinued if pregnant.RESULTS: The mean endometrium thickness in the control group vs.treatment group was(7.3±1.7 mm vs.10.3±2.1 mm),showing statistically significant differences(P < 0.05).In the control group,23%(14/60)achieved pregnancy,with 6,4 and 4 cases at 1,2 and 3 months,respectively,and 42%(6/14) had threatened abortion;in the treatment group,50%(30/60)achieved pregnancy,with 14,10 and 6 cases at 1,2 and 3 months,respectively,and 26%(8/30) had threatened abortion,showing statistically significant differences(P<0.05).CONCLUSION: Addition of bromocriptine to clomifene citrate tablets may improve the pregnancy rate with remarkable efficacy for infertile patients with normal prolactin level.