Side of onset does not influence cognition in newly diagnosed untreated Parkinson's disease patients |
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Authors: | Roberto Erro Gabriella Santangelo Marina Picillo Carmine Vitale Marianna Amboni Katia Longo Flavio Giordano Marcello Moccia Paolo Barone Maria Teresa Pellecchia |
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Institution: | 1. University Federico II, Naples, Department of Neurological Science, Italy;2. Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy;3. IDC Hermitage – Capodimonte, Italy;4. University Parthenope, Naples, Italy;5. University of Salerno, Center for Neurodegenerative Diseases – CEMAND, Via S. Allende, 84081 Baronissi, SA, Italy |
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Abstract: | BackgroundA relation between the side of motor onset and cognitive impairment in early PD has been reported, suggesting that the asymmetric degeneration affecting subcortical regions may play a pivotal role in lateralized cognitive function. However, evidences are controversial and all previous studies were performed on treated patients, though it is known that dopaminergic therapy can affect cognition in PD.MethodsSixty-nine early untreated PD patients underwent an extensive neuropsychological battery exploring memory, visuospatial and attention/executive functions. Patients were divided with respect of the side of onset (right vs. left) and further grouped according to motor phenotype (tremor vs. rigidity-bradykinesia). Multivariate analysis of variance has been carried out to compare clinical and neuropsychological data between subgroups.ResultsThere were no differences in any neuropsychological task between right-sided and left-sided onset subgroups, irrespective of tremor dominant or rigid-bradykinetic phenotype. Age at onset was significantly higher in patients with any cognitive impairment as compared with patients without (66.7 ± 3.2 vs. 56.3 ± 6.8 years, p = 0.001).ConclusionSide of motor onset is not a major determinant for developing lateralized cognitive deficits in newly diagnosed untreated PD patients. |
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