| 循环肿瘤细胞与口腔鳞状细胞癌相关性的研究进展 |
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| 引用本文： | 甘建国,高攀,王晓毅. 循环肿瘤细胞与口腔鳞状细胞癌相关性的研究进展[J]. 国际口腔医学杂志, 2021, 48(2): 205-212 |
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| 作者姓名： | 甘建国 高攀 王晓毅 |
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| 作者单位： | 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院头颈肿瘤外科 成都 610041;口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院全科门诊及急诊科 成都 610041 |
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| 基金项目： | 四川大学华西口腔医院基础与应用基础研究项目(RD-02-201914)。 |
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| 摘 要： | 循环肿瘤细胞(CTCs)是从原发灶部位脱落、释放并转移到血液循环的肿瘤细胞,目前广泛应用于肺癌、乳腺癌等恶性肿瘤的早期诊断、治疗、疗效评价和预后判断,但是在口腔鳞状细胞癌(OSCC)中运用较少且缺乏相关的临床证据.有研究表明,CTCs是OSCC相对独立的预后指标,而且是复发或转移的重要原因之一.本文为深入阐述OSCC中...
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| 关 键 词： | 循环肿瘤细胞 口腔鳞状细胞癌 预后 |
Research progress on the relationship between circulating tumor cells and oral squamous cell carcinoma |
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| Gan Jianguo,Gao Pan,Wang Xiaoyi. Research progress on the relationship between circulating tumor cells and oral squamous cell carcinoma[J]. Journal of International Stomatology, 2021, 48(2): 205-212 |
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| Authors: | Gan Jianguo Gao Pan Wang Xiaoyi |
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| Affiliation: | (State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of Head and Neck Oncology,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of General and Emergency Dentistry,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China) |
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| Abstract: | Circulating tumour cells(CTCs)are tumour cells that disseminate from primary lesion into the peripheral circulating blood.Studies have linked CTCs to the early diagnosis,therapy,therapeutic evaluation and prognostic assessment of cancers,particularly breast and lung cancers.However,CTCs are seldom used in oral squamous cell carcinoma(OSCC),and their value in OSCC lacks clinical evidences.Current evidence has shown that CTCs are a relatively independent prognostic factor and one of the most important reasons of the recurrence and metastasis of OSCC.This paper reviews the current research status of CTCs in OSCC to further elaborate the mechanism of CTCs formation in OSCC and its detection techniques,explore the clinical importance of the biomarkers of OSCC-related CTCs and understand the progression and prognostic relationship between CTCs and OSCC. |
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| Keywords: | circulating tumor cells oral squamous cell carcinoma prognosis |
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