Involvement of specific executive functions in mobility in Parkinson's disease |
| |
| Authors: | Katrijn Smulders Marlies van Nimwegen Marten Munneke Bastiaan R. Bloem Roy P.C. Kessels Rianne A.J. Esselink |
| |
| Affiliation: | 1. Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, The Netherlands;2. HAN University of Applied Sciences, Institute for Studies in Sports and Exercise, Nijmegen, The Netherlands;3. Radboud University Nijmegen Medical Centre, Nijmegen Centre for Evidence Based Practice, Department of Neurology, Nijmegen, The Netherlands;4. Radboud University Nijmegen Medical Centre, Nijmegen Centre for Evidence Based Practice, Scientific Institute for Quality of Healthcare, Nijmegen, The Netherlands;5. Radboud University Nijmegen Medical Centre, Departments of Medical Psychology and Geriatric Medicine, Nijmegen, The Netherlands;6. Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands |
| |
| Abstract: | Postural instability and gait disorders (PIGD) in Parkinson's disease (PD) seem to be associated with executive dysfunction. We investigated which specific executive functions are associated with functional mobility in mildly affected PD patients. Functional mobility (Timed Up&Go Test, TUG), PIGD score, (spatial) working memory, set shifting, response inhibition and response generation were assessed in a large cohort of 232 non-demented PD patients. Both performance on the TUG and PIGD score were weakly associated with working memory and response generation (semantic and phonemic fluency). TUG also correlated with semantic fluency when corrected for disease severity and age. These results indicate that response generation and working memory are associated with (and possibly also causally related to) gait and balance deficits. In order to fully interpret gait and postural stability of PD patients in everyday situations, the role of impairments in working memory and response generation should be taken into account. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
