同期多原发肺癌诊断标准更新与分子遗传学特征研究进展

由于高分辨率胸部CT和肺癌早期筛查的普及,同期多原发肺癌(或称同时性多原发肺癌,synchronous multiple primary lung cancer,sMPLC)的检出率逐步提高。sMPLC与肺癌肺内转移的鉴别诊断成为尤其重要的临床问题。借助高通量测序技术刻画sMPLC的分子遗传学特征是目前研究的热点,既能阐释sMPLC的发生发展规律,也可作为临床病理诊断标准的补充和完善。本文对sMPLC诊断标准的更新进行总结,并以克隆性分析领域为例,综述sMPLC分子遗传学特征的研究进展。

Progresses on diagnostic criteria and genetic features of synchronous multiple primary lung cancer

With the broad application of high-resolution computed tomography(CT)and high rates of early lung cancer screening,the number of patients diagnosed with synchronous multiple primary lung cancer(sMPLC)has been increasing.It becomes of great prominence to distinct sMPLC from intrapulmonary metastases in clinical practice.An increasing number of studies have developed high-throughput sequencing based genetic approaches to specify the molecular characteristics of sMPLC,which contributes to a better understanding of its tumorigenesis.The genetic profile of sMPLC also benefits its diagnosis,which mainly relies on its clinicopathological criteria.Here,we summarize the progresses on the diagnostic criteria for sMPLC,and also molecular features of sMPLC from the perspective of clonality analysis.