| 远志皂苷对快速脑老化鼠学习记忆能力的改善及对神经递质的影响 |
| |
| 引用本文： | 郑璐,邱蕾,张瑶,冯天骄,于建春,张占军. 远志皂苷对快速脑老化鼠学习记忆能力的改善及对神经递质的影响[J]. 北京中医药大学学报, 2010, 33(3): 183-186 |
| |
| 作者姓名： | 郑璐 邱蕾 张瑶 冯天骄 于建春 张占军 |
| |
| 作者单位： | 北京师范大学认知神经科学与学习国家重点实验室,北京,100875;天津中医药大学第一附属医院 |
| |
| 基金项目： | 国家自然科学基金资助项目(No.30873458);;全国优秀博士论文专项基金资助项目(No.2007B7);;北京市新医药学科群资助项目(No.100270569) |
| |
| 摘 要： | 目的探讨远志皂苷对脑老化鼠学习记忆能力的改善作用及对脑内单胺类神经递质的影响。方法采用SAM系列老化鼠为研究对象,将SAMP8随机分为模型组、远志皂苷治疗组、安理申治疗组,将SAMR1作为对照组。连续灌胃治疗3个月后,分别应用Morris水迷宫、高效液相法评估各组小鼠治疗前后的学习记忆能力及脑内神经递质5-羟色胺(5-HT)、5-羟吲哚乙酸(5-HIAA)、多巴胺(DA)、去甲肾上腺素(NE)的含量变化。结果远志皂苷组在第2～5天的隐蔽平台实验中的逃避潜伏期分别为(43.56±10.87)s、(41.37±9.71)s、(37.62±10.05)s、(41.60±13.61)s,在第9天的反向实验中的逃避潜伏期为(37.10±14.04)s,与模型组相比均显著缩短,差异具有统计学意义(P<0.05);远志皂苷组5-HT、5-HIAA、DA、NE的含量分别为(5.95±0.93)mmol/L、(4.43±1.08)mmol/L、(2.61±0.87)mmol/L、(9.44±3.76)mmol/L,与模型组相比均有显著提高,差异具有统计学意义(P<0.05)。结论远志皂苷可以改善脑老化鼠的学习记忆能力,这种作用...
|
| 关 键 词： | 远志皂苷 老化 学习记忆 神经递质 小鼠 |
Influences of tenuigenin on learning and memory ability and neurotransmitters in senescence-accelerated mice |
| |
| ZHENG Lu,QIU Le,ZHANG Yao,FENG Tian-jiao,YU Jian-chun,ZHANG zhan-jun. Influences of tenuigenin on learning and memory ability and neurotransmitters in senescence-accelerated mice[J]. Journal of Beijing University of Traditional Chinese Medicine, 2010, 33(3): 183-186 |
| |
| Authors: | ZHENG Lu QIU Le ZHANG Yao FENG Tian-jiao YU Jian-chun ZHANG zhan-jun |
| |
| Affiliation: | 1#;1 State Key Laboratory of Cognitive Neuroscience and Learning/a>;Beijing Normal University/a>;Beijing 100875/a>;2 First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine |
| |
| Abstract: | Objective To discuss the improving effect of tenuigenin on learning and memory ability and its influence on cerebral monoamine neurotransmitters in senescence-accelerated mice prone 8(SAMP8). Methods The senescence-accelerated mice(SAMP8) were chosen as subjects,and then randomly divided into the model group,tenuigenin group and Donepezil group.SAMR1 were chosen into the the control group.After intragastrical treatment for 3 months,the learning and memory ability and the levels of 5-hydroxytryptamine(5-HT),... |
| |
| Keywords: | tenuigenin senescence learning and memory neurotransmitters mice |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
