Effect of sucralfate on gastric intramucosal pH in critically ill patients |
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| Authors: | X. Calvet F. Baigorri M. Duarte D. Joseph P. Saura A. Mas C. Royo A. Artigas |
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| Affiliation: | (1) Internal Medicine Department, Hospital de Sabadell, Parc Tauli s/n, Sabadell 08208, Barcelona, Spain, ES;(2) Intensive Care Department, Hospital de Sabadell, Parc Tauli s/n, E-08208 Sabadel, Barcelona, Spain, FAX: + 34 (3) 723 3863, e-mail: xcalvet@siberia.chpt.es, ES;(3) Molecular Biology and Physiology Department, Universidad Autonoma de Barcelona, Barcelona, Spain, ES |
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| Abstract: | Objective: To determine whether sucralfate administration affects the tonometric measurement of gastric intramucosal pH (pHi). Design: Non-randomized observational study. Setting: General intensive care unit of a teaching hospital. Patients: Twenty critically ill, mechanically ventilated, consecutively admitted patients requiring an arterial catheter and nasogastric tube. Interventions: Tonometer placement and sucralfate administration. Measurements and main results: We simultaneously determined tonometer saline PCO2 (PCO2i), arterial blood gases, pH of gastric juice and pHi. These parameters were evaluated immediately before sucralfate administration, and 2 h and 4 h after. We did not detect any change in either PCO2i or pHi after sucralfate administration (PCO2i: basal 6.4 ± 1.7, 2 h 6.3 ± 1.7, 4 h 6.3 ± 1.7; pHi: basal 7.35 ± 0.13, 2 h 7.36 ± 0.12, 4 h 7.36 ± 0.12). Conclusions: Sucralfate does not affect the tonometric measurement of PCO2i and pHi. Received: 21 August 1996 Accepted: 18 April 1997 |
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| Keywords: | Sucralfate Gastric intramucosal pH Tonometry Critically ill patients |
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