| 实验性糖尿病大鼠肝,肾,心,脑脂肪酸代谢的动态变化 |
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| 引用本文： | 胡启之. 实验性糖尿病大鼠肝,肾,心,脑脂肪酸代谢的动态变化[J]. 江苏医药, 1994, 20(1): 5-7 |
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| 作者姓名： | 胡启之 |
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| 作者单位： | 江苏省卫生防疫站!210009 |
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| 摘 要： | 报道对链脲佐菌素（STZ）诱导的实验性糖尿病大鼠几种重要脏器（肝、肾、心、脑）卵磷脂、脑磷脂中脂肪酸构成的变化。不饱和脂肪酸变化的模式（C18：2n-6，C20：3n-6，C22：5n-3，C22：6n-3增加，C20：4n-6降低）基本相同，改变的先后顺序是肝→心、肾→脑。
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| 关 键 词： | STZ大鼠 PUFA代谢 动态观察 |
A Consecutive Study on Fatty Acid Metabolism in Liver Kidney Heart and Brain in STZ Induced Diabetic Rats |
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| Hu Qizhi. A Consecutive Study on Fatty Acid Metabolism in Liver Kidney Heart and Brain in STZ Induced Diabetic Rats[J]. Jiangsu Medical Journal, 1994, 20(1): 5-7 |
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| Authors: | Hu Qizhi |
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| Affiliation: | Jiangsu Provincial Sanitary and Anti-epidemic Station |
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| Abstract: | Diabetes exerts profound impacts on phospholipid metabolism. This report presents the results of a consecutive study, from 4 days to 2 months after the injection of streptozotocin (STZ), on the variations of fatty acid composition in phosphocholine and phosphoethanolamine in visceral organs (liver, kidney and heart) and brain. In STZ induced diabetic rats, the variation pattern of PUFA, i. e. increase in levels of (n-6) fatty acids (C18: 2, C20: 3) and (n-3)C22: 6, and decrease in level of (n-6)C20: 4 is basically the same. The changes begin from liver, and then heart and kidney, brain lags the last. |
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| Keywords: | STZ rats PUFA metabolism Consecutive observation |
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