鲁豫两省恙虫病东方体感染流行病学Meta分析

目的:综合分析山东、河南两省恙虫病流行病学特征,对防治本病提供科学依据。方法:采用Meta分析法对两省发表的恙虫病和恙虫病东方体(Ot)感染相关资料进行汇总、归纳和统计分析。结果:共检索105篇文献,从血清学和流行病学或分子生物学证实山东、河南两省存在恙虫病自然疫源地。山东疫情波及40余县市,河南省波及15个县市。患者分布广泛,农民为主占80%以上,青壮年为主;发病高峰在10月,属秋冬型;临床特征与南方恙虫病有相似,但各地仍有一定差异;山东省认为黑线姬鼠和小盾纤恙螨是主要宿主和主要传播媒介。结论:在山东和河南两省恙虫病患者分布广,疫区呈逐渐扩展趋势,开展本病的防治研究具有明显社会效益和重要军事学意义。

Meta analysis on the epidemiology of Orientia tsutsugamushi infection in Shandong and Henan province

Objective: To understand the epidemiologic characteristics on tsutsugamushi disease and Orientia tsutsugamushi (Ot) infection in Shandong and Henan province, so as to provide evidence for the development of preventive measures on the diseases and Ot infection. Methods :Meta analysis was used for compiling, inducing and processing the data of tsutsugamushi disease and Ot published in the two provinces. Results:105 literatures were found and it was confirmed that there are tsutsugamushi disease natural epidemic focus in Shandong and Henan by the serological, epidemiological and the molecular biological study. Over 40 counties and cities are affected in Shandong and 15 in Henan. Patients were widely distributed, most of whom are youths and adults. Peasants account for over 80%. The peak of disease was in October, indicating the disease to be an autumn-winter type.The clinical characteristics were similar to the south tsutsugamushi disease, but there were some differences in each area. It is considered that the heavy line Japanese fieldmouse and the small filament yang man are the main host and intermedium in Shandong province. Conclusion: The tsutsugamushi disease patients were widely distributed in the provinces of Shandong and Henan, and the epidemic area are expanding gradually. There is obvious social and military significance to carry out a research on preventing and controlling the disease.