血浆N-末端脑钠肽前体水平与急性冠状动脉综合征近期预后的关系

目的探讨血浆N-末端脑钠肽前体(NT-proBNP)水平与急性冠状动脉综合征(ACS)患者近期预后的关系。方法采用ELISA法测定76例ACS患者住院后48h内血浆NT-proBNP水平,并随访1年,观察随访期主要不良心脏事件(MACE)。结果ACS患者住院早期血浆NT-proBNP水平为(513.51±364.69)pg/ml,中位数值为421.50pg/ml,明显高于稳定性心绞痛组(95.61±56.32)pg/ml与对照组(41.75±24.26)pg/ml(P<0.05),且血浆NT-proBNP高于中位数值患者的随访期MACE发生率明显高于NT-proBNP水平低于中位数值者。多元Logistic回归分析显示,血浆NT-proBNP水平与ACS患者1年随访期内MACE发生率独立相关(OR=3.66,95%CI:1.08～12.4P=0.0368)。结论血浆NT-proBNP水平是ACS患者1年随访期内MACE发生的独立预测因素。

Relationship between serum N-terminal probrain natriuretic peptide levels and short-term prognosis in patients with acute myocardial syndrome

Objective To evaluate the correlations of serum N-terminal probrain natriuretic peptide (NT-proBNP) levels and prognosis in patients with acute myocardial syndromes(ACS) during 1-year follow-up.Methods Serum NT-proBNP concentrations were measured by ELISA method within 48h after admission in 76 patients with ACS.The patients were followed up for 1 year and the main adverse cardiovascular events (MACE) were observed and recorded.Results Serum NT-proBNP levels was increased in patients with ACS compared with that in patients with stable angina and normal subjects(P<0.05).The mean value of NT-proBNP concentrations in patients with ACS was 513.51±364.69pg/ml,the medium value was 421.5pg/ml.The incidence of MACE was increased in patients whose serum NT-proBNP concentration was higher than the mediam.Multivariate logistic regress analyisis revealed that NT-proBNP concentration was correlated with the incidence of MACE during follow-up independently(OR=3.66,95%CI:1.08-12.4 P=0.0368).Conclusion Serum NT-proBNP level is a indenpent predictor for 1-year MACE rate in patients with ACS.