Vascularized periosteum and bone regeneration

The osteogenic potential of periosteum is widely recognized. During development, it plays a prominent role in the radial growth of long bones. Similarly, it has a key role in the consolidation of fractures. The physiological function of periosteum in the healthy, mature skeleton remains relatively subtle; however, its detachment from the bone surface reactivates its potential for fibrogenic and osteochondrogenic regeneration. This discreet anatomical structure is actually a reservoir of mesenchymal progenitor cells capable of proliferating and differentiating, by reinitializing cellular and molecular cascades of embryogenesis in mesenchymal tissues. However, given the hitherto limited knowledge of the quantitative potential of periosteum and of the pathways regulating tissue differentiation during regeneration, human applications have remained anecdotal. The findings of several in vivo and in vitro experiments indicate that the maintenance of the periosteum's vascularization stimulates its quantitative potential. The structural organization of the regenerated material in vivo is governed by locoregional biological and mechanical regulatory mechanisms that serve to make it capable of performing its new functions. The increasing awareness of periosteum's potential is stimulating active research in the fields of cellular biology and tissue engineering. The demonstration of its regenerative potential in animals gives reason to believe that strips of vascularized periosteum could become part of the developing armamentarium of regenerative medicine.