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Immunological responses to pneumococcal vaccine in frail older people |
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| Authors: | I Ridda CR MacIntyre R Lindley Z Gao JS Sullivan FF Yuan PB McIntyre |
| Institution: | 1. National Centre for Immunization Research and Surveillance Sydney, NSW, Australia;2. The University of Sydney, Sydney, NSW, Australia;3. Discipline of Medicine, Geriatric Medicine. Westmead Hospital, Sydney, NSW, Australia;4. School of Public Health and Community Medicine, The University of New South Wales, Australia;5. The Australian Red Cross Blood Services, Sydney, NSW, Australia;6. Research Unit of Transfusion Medicine and Immunogenetics, Faculty of Medicine, University of Sydney, Australia |
| Abstract: | Advanced age has been associated with a wide range of defects in both the innate and adaptive immune systems including diminished specific antibody responses that increase the risk of invasive pneumococcal disease (IPD) and limit the effectiveness of vaccines. However, the elderly are a heterogeneous group and measures of overall frailty may be a better indicator of disease susceptibility (or vaccine response) than chronological age alone. |
| Keywords: | Pneumococcal disease Frail Older people Pneumococcal vaccines Immune responses |
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