精神分裂症患者及一级亲属童年创伤与功能失调性态度和述情障碍相关性研究

目的：探讨精神分裂症患者及一级亲属童年创伤与功能失调性态度和述情障碍的关系。方法采用童年创伤问卷、功能失调性态度问卷和多伦多述情障碍量表对52例精神分裂症患者（患者组）、48名精神分裂症患者一级亲属（亲属组）及48名健康者（对照组）进行测评分析。结果3组3个量表评分比较差异均有极显著性（P＜0．01），其中患者组功能失调性态度问卷和多伦多述情障碍量表总分显著高于亲属组（ P＜0．05或0．01），亲属组显著高于对照组（ P＜0．05或0．01）；患者组童年创伤问卷总分显著高于亲属组和对照组（P＜0．01），亲属组高于对照组，但差异无显著性（P＞0．05）。相关分析显示，患者组多伦多述情障碍量表总分与功能失调性态度问卷总分及童年创伤问卷总分呈两两显著相关性（P＜0．01）。回归分析发现，功能失调态度可以直接预测述情障碍，在童年创伤和述情障碍的关系中起着完全中介作用。结论精神分裂症患者的童年创伤经历和功能失调性态度及述情障碍水平均高于一级亲属及健康者，而一级亲属的功能失调性态度及述情障碍水平均高于健康者。功能失调性态度是影响述情障碍的主要因素，童年创伤通过功能失调性态度的完全中介效应对述情障碍产生影响。

Correlation study among childhood trauma,dysfunctional attitude and alexithymia of schizophrenics patients and thei r fi rst-degree relatives

Objective To explore the relationship among childhood trauma ,dysfunctional attitude and alexithymia of schizophrenics and their first-degree relatives .Methods Assessments were conducted with the Childhood Trauma Questionnaire （CTQ） ,Dysfunctional Attitude Scale （DAS） and Toronto Alexithymia Scale （TAS） in 52 schizophrenics （patient group） ,48 patients’ first-degree relatives （relative group） and 48 healthy subjects （control group） .Results There were significant differences in 3 scale scores among three groups （P〈0 .01） ,the TAS and DAS total score were significantly higher in patient than control group （P〈0 .05 or 0 .01） ,so were those in relative than control group （P〈0 .05 or 0 .01）;the CTQ total score was significantly higher in patient than relative and control group （P〈0 .01） ,that higher in relative than control group ,but difference wasn’t significant （P〉0 .01） .Correlation analyses showed that there were two-two significant correlation among the TAS ,DAS and CTA total score （P〈0 .01） .Regression analyses discovered that dysfunctional attitude could directly predict alexithymia and played a complete mediation in the relationship between childhood trauma and alexithymia .Conclusion Schizophrenics’ childhood trauma experience ,dysfunctional attitudes and alexithymia levels are all higher compared their first-degree relatives and healthy subjects and so are dysfunctional attitudes and alexithymia levels of first-degree relatives compared with healthy subjects .Dysfunctional attitude is main factor influencing alexithymia ,childhood trauma influence alexithymia via complete mediation effect of dysfunctional attitudes .