草酸艾司西酞普兰联合无抽搐电休克治疗抑郁症对照研究

目的：探讨草酸艾司西酞普兰联合无抽搐电休克治疗抑郁症的临床疗效和安全性以及对认知功能的影响。方法将94例抑郁症患者随机分为两组，两组均口服草酸艾司西酞普兰治疗，观察组联合无抽搐电休克治疗，观察8周。采用汉密顿抑郁量表评定临床疗效，威斯康星卡片分类任务测验评定认知功能，副反应量表评定不良反应。结果治疗后两组汉密顿抑郁量表评分均较治疗前显著下降（ P＜0．05或0．01），观察组较对照组下降更显著（ P＜0．05或0．01）；威斯康星卡片分类任务测验总正确数、完成分类数均呈持续性升高，观察组较对照组升高更显著（ P＜0．05或0．01）；总错误数均呈持续性下降，观察组较对照组下降更显著（ P＜0．05或0．01）；治疗8周末观察组显效率显著高于对照组（P＜0．05）。两组不良反应均轻微，发生率比较差异无显著性（P＞0．05）。结论草酸艾司西酞普兰联合无抽搐电休克治疗抑郁症起效快、疗效显著，能显著改善患者的认知功能，安全性高，依从性好，显著优于单用草酸艾司西酞普兰治疗。

A control study of escitalopram oxalate combined with MECT in the treatment of depression

Objective To explore the efficacy and influence on cognitive function of escitalopram oxalate combined with modified electroconvulsive therapy （MECT） in depression . Methods Ninety-four depression patients were randomly divided into two groups ,both groups took orally escitalopram oxalate ,and observation was plus MECT for 8 weeks .Clinical efficacies were assessed with the Hamilton Depression Scale （HAMD） ,cognitive functions with the Wisconsin Card Sorting Test （WSCT ） ,and adverse reactions with the Treatment Emergent Symptom Scale （TESS） . Results The HAMD scores of both groups low-ered more significantly after treatment compared with pre-treatment （P〈0 .05 or 0 .01） ,so did that in observation than control group （P〈0 .05 or 0 .01）;WCST total correct number and categories completed of both groups heightened continuously ,those did more significantly in observation than control group （P〈0 .05 or 0 .01）;total error numbers lowered continuously ,that did more significantly in observation than control group （P〈0 .05 or 0 .01）;obvious effective rate was significantly higher in observation than control group （P〈 0 .05） .Adverse reactions of both groups were mild ,their incidences had no significant group differences （P〉0 .05） .Conclusion Escitalopram oxalate tablets combined with MECT take effect more rapidly ,have an evident effect ,could notably improve patients’ cognitive functions ,and have higher safety and better compliance compared single escitalopram oxalate in the treatment of depression .