托里消毒散对手术前后肝癌患者细胞免疫功能的影响

目的探讨托里消毒散对调节肝癌患者细胞免疫功能的作用.方法选择可手术切除的肝癌患者38例,随机分两组.Ⅰ组20例,在肝癌切除术前和术后第7天服用中药托里消毒散,服药前后检测T淋巴细胞亚群(CD3、CD4、CD8)和肝功能[谷草转氨酶(AST)、谷丙转氨酶(ALT)、直接胆红素(DBIL)、间接胆红素(IBIL)];Ⅱ组18例,不服用托里消毒散,在与Ⅰ组相应的时期检测T淋巴细胞亚群和肝功能.T淋巴细胞亚群的测定采用单克隆抗体标记直接免疫花环法.结果Ⅰ组患者CD3、CD4、CD4/CD8显著升高,术后AST、ALT、DBIL、IBIL降低;Ⅱ组无明显变化.结论肝癌切除术前和术后服用托里消毒散均可提高患者的细胞免疫功能,术后服用还可明显改善患者的肝功能.

Effect of Tuoli Xiaodu Powder on Cell-Mediated Immunofunction in Liver Carcinoma Patients before and after Surgical Operation

OBJECTIVE: To explore the regulatory effect of Tuoli Xiaodu Powder (TLXDP) on cell mediated immunofunction (T-lymphocytes subsets) in liver carcinoma patients. METHODS: Thirty-eight patients with operable liver carcinoma were divided randomly into 2 groups. TLXDP was given to the 20 cases in Group I before and 7 days after surgical operation, but not given to the 18 cases in Group II. T-lymphocyte subsets (CD3, CD4 and CD8 by monoclonal antibody labelled direct immune rosette method) and liver function, aspartate aminotransferase (AST), alanine transaminase (ALT), direct and indirect bilirubin (DBIL and IBIL) were determined before and after treatment. RESULTS: T-lymphocyte subsets elevated and liver function enhanced significantly in Group I after treatment, but unchanged in Group II. CONCLUSION: Administration of TLXDP before and after surgical operation could enhance the cell-mediated immunofunction and improve the liver function significantly in patients with liver carcinoma.