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Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism |
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| Authors: | Krylatov A V Uzhachenko R V Maslov L N Bernatskaya N A Makriyannis A Mechoulam R Pertwee R G Sal'nikova O M Stefano J B Lishmanov YuB |
| Affiliation: | (1) Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Israel;(2) Tomsk State Pedagogical University, USA;(3) Pharmaceutical School, University of Connecticut, USA;(4) Jerusalem University, Israel;(5) Aberdeen University, Aberdeen, United Kingdom;(6) Department of Surgery, New York State University, Stony Brook, USA |
| Abstract: | Stimulation of cannabinoid receptors with endogenous cannabinoid anandamide and its enzyme-resistant analogue R-(+)-methanandamide improved cardiac resistance to arrhythmias induced by coronary occlusion and reperfusion. This antiarrhythmic effect was not associated with activation of NO synthase, since pretreatment with NG-nitro-L-arginine methyl ester had no effect on the incidence of ischemia/reperfusion-induced arrhythmias. Blockade of ATP-dependent K+ channels with glybenclamide did not abolish the antiarrhythmic effect of R-(+)-methanandamide. Antiarrhythmic activity of endogenous cannabinoids is probably associated with their direct effects on the myocardium. |
| Keywords: | cannabinoid receptors arrhythmias endogenous cannabinoids |
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