| Repair of radius defect with bone-morphogenetic-protein loaded hydroxyapatite／collagen-poly（ L-lactic acid）composite |
| |
| 引用本文： | 胡蕴玉,张超,吕荣,徐建强,李丹. Repair of radius defect with bone-morphogenetic-protein loaded hydroxyapatite／collagen-poly（ L-lactic acid）composite[J]. 中华创伤杂志(英文版), 2003, 6(2): 67-74 |
| |
| 作者姓名： | 胡蕴玉 张超 吕荣 徐建强 李丹 |
| |
| 作者单位： | DepartmentofOrthopaedicsandTraumatologyXijingHospital,TheFourthMilitaryMedicalUniversity,Xi＇an710032,China |
| |
| 摘 要： | Objective: To explore the method to repair bone defect with bone-morphogenetic-protein loaded hydroxyapatite/collagen-poly ( L-lactic acid) composite. Methods: 18 adult beagle dogs were randomly divided into 3 groups. In Group A, bone-morphogeneticprotein ( BMP ) loaded hydroxyapatite/collagen-poly ( L-lactic acid) (HAC-PLA) scaffold was implanted in a 2 cm diaphyseal defect in the radius. In Group B, unloaded pure HAC-PLA scaffold was implanted in the defects. No material was implanted in Group C (control group). The dogs were sacrificed 6 months postoperatively. Features of biocompatibility, biodegradability and osteoinduction were evaluated with histological, radiological examinations and bone mineral density (BMD) measurements. Results: In Group A, the radius defect healed after the treatment with BMP loaded HAC-PLA. BMD at the site of the defect was higher than that of the contralateral radius. Fibrous union developed in the animals of the control group. Conclusions: BMP not only promotes osteogenesis but also accelerates degradation of the biomaterials.Optimized design parameters of a three-dimensional porous biomaterial would give full scope to the role of BMP as an osteoinductive growth factor.
|
| 关 键 词： | 骨形态发生蛋白 放射损伤 羟磷灰石 胶原聚乙烯 L乳汁酸 骨损伤 |
Repair of radius defect with bone-morphogenetic-protein loaded hydroxyapatite/collagen-poly(L-lactic acid) composite |
| |
| Yun-Yu Hu,Chao Zhang,Rong Lu,Jian-Qiang Xu,Dan Li. Repair of radius defect with bone-morphogenetic-protein loaded hydroxyapatite/collagen-poly(L-lactic acid) composite[J]. Chinese journal of traumatology, 2003, 6(2): 67-74 |
| |
| Authors: | Yun-Yu Hu Chao Zhang Rong Lu Jian-Qiang Xu Dan Li |
| |
| Affiliation: | Department of Orthopaedics and Traumatology,Xijing Hospital,The Fourth Military Medical University,Xi'an 710032,China |
| |
| Abstract: | Objective: To explore the method to repair bone defect with bone-morphogenetic-protein loaded hydroxyapatite/collagen-poly(L-lactic acid) composite. Methods: 18 adult beagle dogs were randomly divided into 3 groups. In Group A, bone-morphogenetic-protein (BMP) loaded hydroxyapatite/collagen-poly(L-lactic acid) (HAC-PLA) scaffold was implanted in a 2 cm diaphyseal defect in the radius. In Group B, unloaded pure HAC-PLA scaffold was implanted in the defects. No material was implanted in Group C (control group). The dogs were sacrificed 6 months postoperatively. Features of biocompatibility, biodegradability and osteoinduction were evaluated with histological, radiological examinations and bone mineral density (BMD) measurements. Results: In Group A, the radius defect healed after the treatment with BMP loaded HAC-PLA. BMD at the site of the defect was higher than that of the contralateral radius. Fibrous union developed in the animals of the control group. Conclusions: BMP not only promotes osteogenesis but also accelerates degradation of the biomaterials. Optimized design parameters of a three-dimensional porous biomaterial would give full scope to the role of BMP as an osteoinductive growth factor. |
| |
| Keywords: | Bone substitute materials poly(L-lactic acid) Hydroxyapatite Collagen Bone morphogenetic protein |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
