| Changes of pulmonary intercellular adhesion molecule-1 and CD11b／CD18 in peripheral polymorphonuclear neutrophils and their significance at the early stage of burns |
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| 引用本文： | 金榕兵,朱佩芳,王正国,刘大维,周继红. Changes of pulmonary intercellular adhesion molecule-1 and CD11b／CD18 in peripheral polymorphonuclear neutrophils and their significance at the early stage of burns[J]. 中华创伤杂志(英文版), 2003, 6(3): 156-159 |
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| 作者姓名： | 金榕兵 朱佩芳 王正国 刘大维 周继红 |
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| 作者单位： | ResearchInstituteofSurgery,ThirdMilitaryMedicalUniversity,Chongqing400042,China |
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| 摘 要： | Objective: To investigate the role of intercellular adhesion molecule-1 (ICAM-1) in the accumulation of polymorphonuclear neutrophils (PMN) in the lungs at the early stage of burns. Methods: Myeloperoxidase content in lung tissues and bronchoalveolar lavage fluid (BALF) were detected.ICAM-1 and its mRNA expression in lung tissues were determined bycal method and in situ hybridization. CD11b/CD18 expression on the peripheral PMNs was measured by flowcytometry. Results : The levels of myeloperoxidase in lung tissues and BALF after burn injury were markedly higher than those of control. Expression of ICAM-1 and its mRNA in the lung tissues and CD11b/CD18 on peripheral PMNs surface was significantly increased at 2, 6, 12, 24 h after burns. Conclusions. PMNs accumulation in the lungs is related to increased ICAM-1 expression on pulmonary microvascular endothelial cells and CD11b/CD18 expression on PMN at the early stage of burn injury.
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| 关 键 词： | 细胞间粘附分子-1 嗜中性白细胞 肺部 烧伤 髓过氧化物酶 外周血 临床意义 |
Changes of pulmonary intercellular adhesion molecule-1 and CD11b/CD18 in peripheral polymorphonuclear neutrophils and their significance at the early stage of burns |
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| JIN Rong bing ,ZHU Pei fang,WANG Zheng guo,LIU Da wei and ZHOU Ji hong. Changes of pulmonary intercellular adhesion molecule-1 and CD11b/CD18 in peripheral polymorphonuclear neutrophils and their significance at the early stage of burns[J]. Chinese journal of traumatology, 2003, 6(3): 156-159 |
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| Authors: | JIN Rong bing ZHU Pei fang WANG Zheng guo LIU Da wei ZHOU Ji hong |
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| Affiliation: | Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China |
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| Abstract: | Objective: To investigate the role of intercellular adhesion molecule 1 (ICAM 1) in the accumulation of polymorphonuclear neutrophils (PMN) in the lungs at the early stage of burns. Methods: Myeloperoxidase content in lung tissues and bronchoalveolar lavage fluid (BALF) were detected. ICAM 1 and its mRNA expression in lung tissues were determined by immunohistochemical method and in situ hybridization. CD11b/CD18 expression on the peripheral PMNs was measured by flowcytometry. Results: The levels of myeloperoxidase in lung tissues and BALF after burn injury were markedly higher than those of control. Expression of ICAM 1 and its mRNA in the lung tissues and CD11b/CD18 on peripheral PMNs surface was significantly increased at 2, 6, 12, 24 h after burns. Conclusions: PMNs accumulation in the lungs is related to increased ICAM 1 expression on pulmonary microvascular endothelial cells and CD11b/CD18 expression on PMN at the early stage of burn injury. |
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| Keywords: | Burns Endothelium vascular Intercellular adhesion molecule 1 |
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