|
|||||
|
|
| Effect of thyrotropin-releasing hormone on cerebral free radical reactions following acute brain injury in rabbits | |
| 作者姓名： | 牛光明 顾秀娟 苏玉林 万锋 苏芳忠 薛德麟 |
| 作者单位： | Department of Neurosurgery，Department of Surgery，Department of Surgery，Department of Neurosurgery，Department of Neurosurgery，Department of Neurosurgery Tongji Hospital，Tongji Medical College，Huazhong University of Technology and Science，Wuhan 430030，China，Department of Neurosurgery，SecondAffiliated Hospital，Zhengzhou University，Zhengzhou450003，China，Second People's Hospital of Zhengzhou City，Zhengzhou 450000，China，Electric Hospital，Zhengzhou 450000，China，Tongji Hospital，Tongji Medical College，Huazhong University of Technology and Science，Wuhan 430030，China，Second Affiliated Hospital，Zhengzhou University，Zhengzhou 450003，China，Tongji Hospital，Tongji Medical College，Huazhong University of Technology and Science，Wuhan 430030，China |
| 摘 要： | Tｈｅｒｅｉｓｎｏｅｆｆｉｃｉｅｎｔｔｈｅｒａｐｅｕｔｉｃｍｅｔｈｏｄｆｏｒｐｒｉｍａｒｙｃｅｒｅｂｒａｌｌｅｓｉｏｎａｆｔｅｒｃｒａｎｉｏｃｅｒｅｂｒａｌｉｎｊｕｒｙｙｅｔａｎｄｗｈａｔｃａｎｂｅｄｏｎｅｉｓｔｏｐｒｅｖｅｎｔａｎｄｔｒｅａｔｓｅｃｏｎｄａｒｙｂｒａｉｎｉｎｊｕｒｙ .Ｌｉｐｉｄｐｅｒｏｘｉｄａｔｉｏｎｏｆｂｒａｉｎｔｉｓｓｕｅｓｉｎｄｕｃｅｄｂｙｔｈｅｉｎｃｒｅａｓｅｄｃｅｒｅｂｒａｌｆｒｅｅｒａｄｉｃａｌｒｅａｃｔｉｏｎｓａｆｔｅｒｃｅｒｅｂｒａｌｉｎｊｕｒｙｉｓｏｎｅｏｆｔ… |
| 关 键 词： | 促甲状腺激素 荷尔蒙 自由基 急性脑损伤 动物实验 |
Effect of thyrotropin-releasing hormone on cerebral free radical reactions following acute brain injury in rabbits |
|
| NIU Guang-ming,GU Xiu-juan,SU Yu-lin,WAN Feng,SU Fang-zhong and XUE De-lin.Effect of thyrotropin-releasing hormone on cerebral free radical reactions following acute brain injury in rabbits[J].Chinese Journal of Traumatology(English Edition),2003,6(2):104-106. | |
| Authors: | NIU Guang-ming GU Xiu-juan SU Yu-lin WAN Feng SU Fang-zhong and XUE De-lin |
| Institution: | 1. Department of Neurosurgery,Tongji Hospital,Tongji Medical College,Huazhong University of Technology and Science,Wuhan 430030,China 2. Department of Surgery,Second People's Hospital of Zhengzhou City,Zhengzhou 450000,China 3. Department of Surgery,Electric Hospital,Zhengzhou 450000,China 4. Department of Neurosurgery,Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450003,China |
| Abstract: | Objective: To investigate the early effect of thyrotropin-releasing hormone (TRH) on cerebral free radical reactions after acute brain injury in rabbits. Methods: 30 healthy white rabbits were randomly divided into three groups: Group A (n=10), Group B (n=12) and Group C (n=8). The rabbits in Group A and Group B were injured by direct hit. At 0.5-4 hours after injury, the rabbits in Group A were injected with TRH ( 8 mg/kg body weight) through a vein and the rabbits in Group B were injected with normal saline of equal volume. The rabbits in Group C served as the normal control. Then all the rabbits were killed and brain tissues were obtained. The content of lipoperoxide (LPO), the activity of superoxide dismutase (SOD) and the water content of the brain tissues were measured. Results: The contents of LPO and water in brain tissues in Group A were lower and the activity of SOD was higher than those of Group B (P< 0.05). After injury, intracranial pressure (ICP) rose rapidly and continuously with time passing by. When TRH was given to the animals in Group A, the rising speed of ICP slowed down significantly. Conclusions: TRH can decrease the cerebral free radical reactions and cerebral edema after acute brain injury in rats. |
| Keywords: | Thyrotropin Free radicals Superoxide dismutase Brain injuries |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |