| Effect of recombinant human basic fibroblast growth factor on angiogenesis during mandible fracture healing in rabbits |
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| 作者姓名： | 龚振宇 周树夏 顾晓明 李涤尘 孙明林 |
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| 作者单位： | Department of Oral-Maxillofacial Surgery，College of Stomatology，Fourth Military Medical University，Xi’an 710032，China，Department of Oral-Maxillofacial Surgery，College of Stomatology，Fourth Military Medical University，Xi’an 710032，China，Department of Oral-Maxillofacial Surgery，College of Stomatology，Fourth Military Medical University，Xi’an 710032，China，Institute of Advanced Manufacturing Technique，Xi’an Jiaotong University，Xi’an 710049，China，Institute of Advanced Manufacturing Technique，Xi’an Jiaotong University，Xi’an 710049，China |
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| 基金项目： | This study was supported by the National Natural Science Foundation of China,No.59975074. |
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| 摘 要： | Objective: To investigate the effect of recombinant human basic fibroblast growth factor ( rhbFGF) on angiogenesis during mandible fracture healing in rabbit.Methods: Fifty adult white rabbits were used for animal model and randomly divided into a control group (25 rabbits) and an experimental group (25 rabbits). The membranous complex of rhbFGF and bovine type I collagen was prepared and implanted into the rabbit mandible fracture site under periosteum. The animals were sacrificed on 7, 14, 28, 56 and 84 days respectively after operation and the whole mandibles were harvested. The expression of factor Vm related antigen (F8-RA) in callus was examined with immimohistochemical staining.Results: The amounts of microvascular formation in calluses in the rhbFGF-treating group on days 7, 14, 28 and 56 were more than those of the control group (P < 0.01).Conclusions: The results indicated that rhbFGF could stimulate microvascular formation during mandible fracture healing in rabbits.
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| 关 键 词： | 重组人基质纤维原细胞生长因子 血管生成 下鄂骨骨折 动物实验 作用机制 |
Effect of recombinant human basic fibroblast growth factor on angiogenesis during mandible fracture healing in rabbits |
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| GONG Zhen-yu,ZHOU Shu-xia,GU Xiao-ming,LI Di-chen and SUN Ming-Jin.Effect of recombinant human basic fibroblast growth factor on angiogenesis during mandible fracture healing in rabbits[J].Chinese Journal of Traumatology(English Edition),2003,6(4):242-244. |
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| Authors: | GONG Zhen-yu ZHOU Shu-xia GU Xiao-ming LI Di-chen and SUN Ming-Jin |
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| Institution: | 1. Department of Oral-Maxillofacial Surgery, College of Stomatology, Fourth Military Medical University, Xi'an 710032, China
2. Institute of Advanced Manufacturing Technique, Xi'an Jiaotong University, Xi'an 710049, China |
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| Abstract: | Objective: To investigate the effect of recombinant human basic fibroblast growth factor ( rhbFGF) on angiogenesis during mandible fracture healing in rabbit.
Methods: Fifty adult white rabbits were used for animal model and randomly divided into a control group (25 rabbits) and an experimental group (25 rabbits). The membranous complex of rhbFGF and bovine type I collagen was prepared and implanted into the rabbit mandible fracture site under periosteum. The animals were sacrificed on 7, 14, 28, 56 and 84 days respectively after operation and the whole mandibles were harvested. The expression of factor Vm related antigen (F8-RA) in callus was examined with immimohistochemical staining.
Results: The amounts of microvascular formation in calluses in the rhbFGF-treating group on days 7, 14, 28 and 56 were more than those of the control group (P < 0.01).
Conclusions: The results indicated that rhbFGF could stimulate microvascular formation during mandible fracture healing in rabbits. |
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| Keywords: | Mandible Fracture healingImmunohistochemistry Recombinant human bask fibroblast growth factor |
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