| Use of a self-designed bladder controller for restoring bladder function in paraplegic dogs |
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| 引用本文： | 王诗波,侯春林,刁颖敏,陈爱民,张世民,雷波,尹承慧,张伟. Use of a self-designed bladder controller for restoring bladder function in paraplegic dogs[J]. 中华创伤杂志(英文版), 2003, 6(4): 195-198 |
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| 作者姓名： | 王诗波 侯春林 刁颖敏 陈爱民 张世民 雷波 尹承慧 张伟 |
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| 作者单位： | [1]DepartmentofOrthopaedics,ChangzhengHospital,SecondMilitaryMedicalUniversity,Shanghai200003,China [2]TongjiUniversity,Shanghai200092,China |
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| 基金项目： | a grant from the National Natural Science Fundation of China(No.30170956). |
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| 摘 要： | Objective: To evaluate the results of a self-designed bladder controller for restoring micturition function in paraplegic dogs. Methods : The spinal cords of 4 dogs were transected above the cone. Electrodes were implanted in S2 bilaterally and connected to the subcutaneous receivers for external activation. Microsurgical technique was employed to perform dorsal rhizotomy of S1-3 intradurally. The dogs were stimulated daily to observe micturition. Urodynamic testing and vesicography were performed. Results: All the dogs acquired micturition under the control of electric stimulation, with urine volume 80-140 ml per time. The mode of micturition was post-stimulus voiding. Vesicography revealed that the bladder was rifled well and the bladder neck was open in the micturition course of electric stimulation. Residual urine volume was 15-20 ml. Urodynamic testing found that the bladder pressure and intraurethral pressure increased simultaneously, but when the intraurethral pressure was greater than the bladder pressure, no micturition occurred.The pressure decreased to baseline rapidly and the bladder pressure decreased slowly between two bursts. Micturition occurred when the bladder pressure was greater than the intraurethral pressure. Conclusions: The self-designed bladder controller together with a sacral deafferentation procedure can restore micturition function of paraplegic dogs.
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| 关 键 词： | 截瘫 膀胱控制器 膀胱功能 动物实验 脊髓损伤 尿路感染 |
Use of a self-designed bladder controller for restoring bladder function in paraplegic dogs |
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| WANG Shi-bo,HOU Chun-lin,DIAO Ying-min,CHEN Ai-min,ZHANG Shi-min,LEI Bo,YIN Cheng-hui and ZHANG Wei. Use of a self-designed bladder controller for restoring bladder function in paraplegic dogs[J]. Chinese journal of traumatology, 2003, 6(4): 195-198 |
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| Authors: | WANG Shi-bo HOU Chun-lin DIAO Ying-min CHEN Ai-min ZHANG Shi-min LEI Bo YIN Cheng-hui ZHANG Wei |
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| Affiliation: | 1. Department of Orthopaedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
2. Tongji University, Shanghai 200092, China |
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| Abstract: | Objective: To evaluate the results of a self-designed bladder controller for restoring micturition function in paraplegic dogs.Methods: The spinal cords of 4 dogs were transected above the cone. Electrodes were implanted in S2 bilaterally and connected to the subcutaneous receivers for external activation. Microsurgical technique was employed to perform dorsal rhizotomy of S1 -3 intradurally. The dogs were stimulated daily to observe micturition. Urodynamic testing and vesicography were performed.Results: All the dogs acquired micturition under the control of electric stimulation, with urine volume 80-140 ml per time. The mode of micturition was post-stimulus voiding. Vesicography revealed that the bladder was filled well and the bladder neck was open in the micturition course of electric stimulation. Residual urine volume was 15-20 ml. Urodynamic testing found that the bladder pressure and intraurethral pressure increased simultaneously, but when the intraurethral pressure was greater than the bladder pressure, no micturition occurred. The pressure decreased to baseline rapidly and the bladder pressure decreased slowly between two bursts. Micturition occurred when the bladder pressure was greater than the intraurethral pressure.Conclusions: The self-designed bladder controller together with a sacral deafferentation procedure can restore micturition function of paraplegic dogs. |
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| Keywords: | Spinal cord injuries Electric stimulation therapy Dogs Bladder function |
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