| 肝硬化肠道细菌易位防治研究进展 |
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| 引用本文： | 陈燕飞,李兰娟. 肝硬化肠道细菌易位防治研究进展[J]. 国际流行病学传染病学杂志, 2007, 34(4): 233-236 |
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| 作者姓名： | 陈燕飞 李兰娟 |
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| 作者单位： | 310003,杭州,浙江大学医学院附属第一医院国家传染病诊治重点实验室(筹),浙江省传染病重点实验室;310003,杭州,浙江大学医学院附属第一医院国家传染病诊治重点实验室(筹),浙江省传染病重点实验室 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)(2003CB515506) |
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| 摘 要： | 肠道细菌易位参与肝硬化各种并发症如自发性细菌性腹膜炎、肝肾综合征、肝肺综合征及肝性脑病等的发生发展。肝硬化时肠道细菌易位发生主要与三方面因素有关:肠道细菌过度生长,肠壁通透性增加及机体免疫力下降。从抑制肠道细菌过度生长,降低肠壁通透性和提高机体免疫力三方面着手,进行肠道细菌易位防治,可以有效控制肝硬化各种并发症的发生发展。
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| 关 键 词： | 肝硬化 细菌易位 肠道 |
Progress in prevention and treatment of intestinal bacterial translocation in cirrhosis |
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| CHEN Yan-fei,LI Lan-juan. Progress in prevention and treatment of intestinal bacterial translocation in cirrhosis[J]. International Journal of Epidemiology and Infectious Disease, 2007, 34(4): 233-236 |
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| Authors: | CHEN Yan-fei LI Lan-juan |
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| Abstract: | Bacterial translocation plays an important role in the pathogenesis of the complications of cirrhosis,such as spontaneous bacterial peritonitis,hepatorenal syndrome,hepatopulmonary syndrome and hepatic encephalopathy.Three factors have been implicated in the development of intestinal bacterial translocation:intestinal bacterial overgrowth,increased intestinal permeability and impaired immunity.So most of the currently tested therapies geared at preventing bacterial translocation are aimed at decreasing bacterial translocation,reducing intestinal permeability and improving immunity.This review summarized the ways to prevent and treat intestinal bacterial translocation in cirrhosis. |
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| Keywords: | Liver cirrhosis Bacterial translocation Intestines |
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