| 轻度转氨酶升高的慢乙肝患者血清HBeAg及HBVDNA与肝组织病理改变的关系 |
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| 引用本文： | 诸葛璐,林巍,潘陈为,方佩佩,周光耀,金玲湘.轻度转氨酶升高的慢乙肝患者血清HBeAg及HBVDNA与肝组织病理改变的关系[J].中国现代医生,2011,49(8):108-110. |
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| 作者姓名： | 诸葛璐 林巍 潘陈为 方佩佩 周光耀 金玲湘 |
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| 作者单位： | 温州医学院附属第二医院成人感染内科,浙江温州,325000 |
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| 基金项目： | 浙江省温州市科技局资助项目 |
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| 摘 要： | 目的探讨ALT正常值1～2倍慢性HBV感染患者肝组织病理特征，分析血清HBeAg、HBVDNA定量与肝组织病理关系。方法选取ALT正常值1～2倍慢性HBV感染者90例，行肝穿刺，比较HBeAg阳性、阴性组及不同HBVDNA定量患者肝组织炎症分级、纤维化分期。结果90例患者均存肝损，病理诊断肝硬化7例，83例病理诊断慢乙肝患者，G≥2者27例（32．53％），S≥2者25例（30．12％）。HBeAg阴性组病理炎症分级、纤维化分期均重于阳性组，不同HBVDNA定量组肝组织炎症分级、纤维化分期差异无统计学意义。结论ALT正常值1～2倍慢性HBV感染者，肝组织病理皆存异常，血清HBeAg、HBVDNA不能反映肝脏受损情况。
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| 关 键 词： | 乙型肝炎病毒 乙型肝炎e抗原 HBV DNA 肝组织病理 |
The Relationship between Serum HBeAg, HBV DNA and Liver Pathological Change in Chronic Hepatitis B Virus Carriers with Slight Unusual Liver Function |
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| Authors: | ZHUGE Lu LIN Wei PAN Chenwei FANG Peipei ZHOU Guangyao JIN Lingxiang |
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| Institution: | ZHUGE Lu LIN Wei PAN Chenwei FANG Peipei ZHOU Guangyao JIN Lingxiang Department of Infectious,the Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China |
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| Abstract: | Objective To explore the relationship between serum HBeAg,the qualification of HBV DNA and the histopathologic change of livers in chronic hepatitis B virus carriers with slight unusual liver function.Methods Liver biopsy,serum and serological examination were performed in 90 randomly selected chronic hepatitis B virus carriers with slight unusual liver function.Groups were divided basedon serum HBeAg and HBV DNA levels.Comparisons of liver inflammation and fibrosis stages were conducted between groups.Resu... |
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| Keywords: | HBV DNA |
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