| 褪黑素对急性重症胰腺炎肝损伤的保护作用 |
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| 引用本文： | 丁琪,赫长胜,薛峰,岳洪义,徐建. 褪黑素对急性重症胰腺炎肝损伤的保护作用[J]. 中国现代医生, 2011, 49(5): 12-13 |
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| 作者姓名： | 丁琪 赫长胜 薛峰 岳洪义 徐建 |
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| 作者单位： | 青岛市胶州中心医院普外科,山东,青岛,266300 |
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| 摘 要： | 目的探讨褪黑素对急性重症胰腺炎（SAP）的大鼠肝损伤的保护作用。方法48只SD大鼠随机分为假手术组（S组）、胰腺炎组（P组）、褪黑素组（T组），每组16只。各组于建立模型后24h抽血测定血淀粉酶（AMY）、丙氨酸转移酶（AIJT）、天门冬氨酸转移酶（AST）、丙二醛（MDA）、超氧化物歧化酶水平（SOD）。结果S组、T组与P组相比，血清AMY、ALT、AST、MDA水平明显降低（P〈0．05），SOD水平明显升高（P〈0．05），T组与S组相比变化更明显。结论褪黑素可以减轻重症胰腺炎时的肝损伤，其机制可能是通过减轻脂质过氧化反应损伤而实现的。
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| 关 键 词： | 急性胰腺炎 褪黑素 肝脏损伤 |
Protection Effects of Melatonin on Against Liver Injury in Severe Acute Pancreatitis |
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| DING Qi,HE Changsheng,XUE Feng,YUE Hongyi,XU Jian. Protection Effects of Melatonin on Against Liver Injury in Severe Acute Pancreatitis[J]. , 2011, 49(5): 12-13 |
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| Authors: | DING Qi HE Changsheng XUE Feng YUE Hongyi XU Jian |
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| Affiliation: | DING Qi HE Changsheng XUE Feng YUE Hongyi XU Jian Department of General Surgery,Jiaozhou Central Hospital of Qingdao City,Qingdao 266300,China |
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| Abstract: | Objective To investigate the protective effects of melatonin on against liver injury in severe acute pancreatitis(SAP).Methods Fouty eight rats were randomly devided into three groups.(group S),SAP group(group P),treatment group with melatonin(group T) with 16 rats eath.24h after establishing the model,The serum levels of amylase(AMY),glutamic pyruvic transaminase(ALT),glutamic oxaloacetic transaminase(AST),and maleic dialdehyde(MDA) and Serum superoxide dismutase(SOD) were detected in each group.Results co... |
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| Keywords: | Acute pancreatitis Melatonin Hepatic injury |
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