新型病毒TTV与乙型肝炎病毒混合感染的初步探讨

目的了解新型肝炎病毒TFV与乙型肝炎病毒（HBV）混合感染对肝脏病变及HBV复制状态的影响。方法套式聚合酶链反应检测乙型肝炎患者血清TTVDNA并对检测结果和临床资料进行统计学分析。结果177例慢性HBV感染者中32例TTVDNA阳性，阳性率18．1％：其中无症状携带者5/52（9．6％），慢性肝炎7/46（15.2％），重型肝炎9/39（23．1％），活动性肝硬化9／40（22．5％），各组间无统计学差异；在慢性肝炎、重型肝炎及活动性肝硬化病人中，TTV阳性者与TTV阴性者的各项肝功能指标及血清HBeAg阳性率无统计学差异；但HBV、TTV混合感染的重型肝炎死亡率较高，具有统计学意义。，结论TTV混合感染似乎不影响HBV所致的肝脏病变及其复制状态，但可能影响重型肝炎的预后。

Clinical analysis of transfusion transmitted virus co-infection in hepatitis B virus infected patients

Objective Recently, a novel DNA virus (transfusion-transmitted virus, TTV) was found in the cryptogenic hepatitispatients. The aim of this study was to find out the influence of TTV co-infection on the pathological process and virus replication inhepatitis B virus-infected patients. Mothods Serum TTV DNA was tested by nested PCR, and the results and clinical data werestatistically analyzed. Results Of 177 hepatitis B virus-infected patients, 32(18. 1%) were co-infected with TTV Among them, 5/52(9.6%) asymptotic carriers, 7/46 (15.2%) patients with chronic hepatitis B, 9/40(22.5%) with active liver.cirrhosis, and 9/39 (23. 1%)with fulminant hepatitis were TTV positive, but there was no statistical difference between the groups (X2=5.997, 0. 10< P<0.25). Ineach type of liver disease, the liver function tests and the positive fates of serum HBeAg showed no difference between simple HBVand co-infection with TTV The mortality of fulminant hepatitis was higher in HBV and TTV co-infection than in HBV singleinfection, with statistical difference (6/8 vs 6/22, P=0.038). Conclusions TTV co-infection could not affect the pathological processand virus replication of HBV, but the prognosis of fulminant hepatitis.