中国老年人群不同肥胖类型与血脂异常关系的meta分析

目的系统评价中国≥60岁老年人群不同肥胖类型与血脂异常的关系。方法检索中英文数据库中与肥胖和血脂异常相关的研究,对符合纳入排除标准的文献进行meta分析。结果最终纳入19篇横断面研究,样本总量为63 844。研究间异质性较大(I~250%),采用随机效应模型合并。多因素meta结果显示,与体质量指数(BMI)正常人群相比,超重和普通肥胖人群患血脂异常的合并OR值分别为1.92(95%CI:1.21~3.05)和2.13(95%CI:1.41~3.22)。与腰围正常人群相比,腹型肥胖人群患血脂异常的风险亦增加(OR=2.00,95%CI:1.47~2.72)。结论我国老年人群肥胖可能显著增加患血脂异常的风险,亟待临床诊疗关注。

Correlation of different types of obesity with dyslipidemia in Chinese aging population:a meta-analysis

Objective To systematically evaluate the relationship of different types of obesity with dyslipidemia in Chinese elderly population over 60 years old. Methods The studies concerning the relationship of obesity and dyslipidemia were retrieved in available Chinese and English databases, and the literatures meeting our inclusion criteria were enrolled, and then quantitative meta-analysis was performed to study the relationship. Results There were 19 cross-sectional studies enrolled in this study, containing totally 63 844 aged people. Random effects model was used because of the considerably high heterogeneity (I²>50%). Compared with the people with normal body mass index (BMI), the multivariate pooled OR was 1.92 (95%CI:1.21-3.05) and 2.13 (95%CI:1.41-3.22) respectively for the overweight and obese people. And the risk of dyslipidemia was significantly higher in the elderly with central obesity than those with normal waist circumference (OR=2.00,5%CI:1.47-2.72). Conclusion Obesity will significantly increase the risk of dyslipidemia in the Chinese elderly population, and more clinical attention should be paid to the problem.