| Abstract: | Speen cells derived from sheep red blood cell (SRBC)-primed nude mice gave a typical secondary response when challenged in vitro with SRBC in the presence of SRBC-primed T cells. The results demonstrate that B memory cells of both IgM and IgG type develop in the absence of functioning T cells. Moreover, these results indicate that Θ-antigen-bearing cells, reactive to phytohemagglutinin (PHA) or concanavalin A (Con A), are not involved in the initiation of B cell triggering, but rather in the differentiation step leading to antibody-forming cells. |
