小儿消化性溃疡幽门螺杆菌感染的相关危险因素分析

正幽门螺杆菌(helicobacter pylori,Hp)与消化性溃疡、慢性胃炎等疾病密切相关~(1])。儿童期是幽门螺杆菌感染的主要阶段,一旦感染终身受累~(2])。研究~(3])显示,小儿消化性溃疡与年龄、生活地区、个人卫生、家族患病史等有一定的关系。本研究从个人卫生、社会情况(父母文化程度、家庭经济、母乳喂养等)、家族史以及血型等多个方面考察小儿消化性

Risk factors of Helicobacter pylori Infection in children with peptic ulcer disease

Objective: To evaluate the risk factors of Helicobacter pylori infection in children with peptic ulcer. Methods: From April 2013 to September 2015, 148 cases of children who were diagnosed with peptic ulcer were divided into HP-negative group (n = 97) and HP-positive group (n = 51) by examining in our hospital. Environmental factors (parents" education, hygiene, family economic conditions, family history and past medical history of gastrointestinal etc.) were investigate by questionnaire. ABO blood group and Lewis blood were detected simultaneously. Risk factors of HP infection in peptic ulcer were analyzed. Results: There was no significant difference in age, gender, and breastfeeding between HP -positive group and HP-negative group (c2=1.87,1.56, P>0.05). Parents" education level, personal hygiene, living area, family economic status, family stomach intestinal diseases, past medical history aspect statistically significant (c2=10.65,11.49,9.66,5.76,17.89,12.51, P>0.05) of HP -positive group were poorer than HP-negative group. Multivariate Logistic regression analysis showed that parents" education level, personal hygiene, life area, family gastrointestinal illness, past medical history, blood type is O, Lewis blood type Le (a + b +) phenotype in children were risk factors for Helicobacter pylori infection in peptic ulcer. Conclusion: The education level of parents, children personal hygiene, living area, family gastrointestinal illness, past medical history, blood type is O, Lewis blood type Le (a + b +) phenotype were risk factors of H. pylori infection in children with peptic ulcer factor, should strengthen children"s education and propaganda, especially type O blood and Le (a + b +) phenotype should pay more attention.