| 盐酸替马沙星的新法合成 |
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| 引用本文： | 虞心红 候志安. 盐酸替马沙星的新法合成[J]. 医学教育探索, 2000, 0(6): 654-656660 |
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| 作者姓名： | 虞心红 候志安 |
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| 作者单位： | 华东理工大学化学与制药工程学院,上海 |
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| 摘 要： | 以２，４－二氯－５－氯苯甲酰乙酸乙酯为原料，经缩合、胺化，环合、螯合，取代，水解及成盐反应合成盐酸替马沙星。经元素分析，红外光谱，质谱和核磁共振谱确证结构，总收率４５％。该工艺路线副反应少，产品纯度高。
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| 关 键 词： | 氟喹诺酮类抗菌剂 盐酸替马沙星 合成 合成工艺 |
Novel Process for Preparation of Temafloxacin Hydrochloride |
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| YU Xin hong,HOU Zhi an,TIAN Zhong yu,CHEN Zhong ying. Novel Process for Preparation of Temafloxacin Hydrochloride[J]. Researches in Medical Education, 2000, 0(6): 654-656660 |
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| Authors: | YU Xin hong HOU Zhi an TIAN Zhong yu CHEN Zhong ying |
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| Abstract: | In search for more reasonable process for preparation of polyfluorated quinolone antibacterial agents, temafloxacin hydrochloride is prepared from ethyl 2,4 dichloro 5 fluorobenzoylacetate, via condensation, amination, cyclization, boron esterification, substitution, hydrolysis and salt formation with 45% overall yield. The structure of temafloxacin hydrochloride is confirmed by MS, 1H NMR, IR and EA. |
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| Keywords: | fluoroquinolone antibacterial agent temafloxacin hydrochloride preparation ethyl 2 4 dichloro 5 fluorobenzoylacetateD |
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