| 猫须草水溶性化学成分的研究 |
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| 引用本文： | 孙照翠,郑庆霞,吴海峰,马国需,许旭东,杨峻山.猫须草水溶性化学成分的研究[J].中国药学杂志,2014,49(1):22-25. |
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| 作者姓名： | 孙照翠 郑庆霞 吴海峰 马国需 许旭东 杨峻山 |
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| 作者单位： | 中国医学科学院北京协和医学院药用植物研究所, 北京 100193
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| 基金项目： | 国家十二五“重大新药创制”创新药物研究开发技术平台建设项目(2012ZX09301-002-001;2011ZX09307-002-01);国家天然药用植物对照品库建设项目(1310981201) |
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| 摘 要： | 目的对猫须草水溶性化学成分进行分离和结构鉴定方法通过多种色谱技术包括大孔树脂、MCI、HPLC等方法进行分离纯化,利用多种波谱技术并结合文献对其结构鉴定。结果从猫须草中分离得到15个化合物,分别鉴定为咖啡酸(1),咖啡酸甲酯(2),咖啡酸乙酯(3),丹参素(4),丹参素乙酯(5),迷迭香酸(6),迷迭香酸甲酯(7),迷迭香酸乙酯(8),isorinic acid(9),二氢松柏醇(10),二氢芥子醇(11),丹酚酸C(12),丹酚酸H(13),3’-O-(8″-Z-caffeoyl)rosmarinic acid methyl ester(14),黄芩素(15)。结论化合物2,4~5及9~15首次从猫须草中分离得到。
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| 关 键 词： | 唇形科 猫须草 二氢松柏醇 二氢芥子醇 丹酚酸C 丹酚酸H |
| 收稿时间： | 2014-03-04; |
Water-soluble Constituents of Clerodendranthus spicatus |
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| SUN Zhao-cui,ZHENG Qing-xia,WU Hai-feng,MA Guo-xu,XU Xu-dong,YANG Jun-shan.Water-soluble Constituents of Clerodendranthus spicatus[J].Chinese Pharmaceutical Journal,2014,49(1):22-25. |
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| Authors: | SUN Zhao-cui ZHENG Qing-xia WU Hai-feng MA Guo-xu XU Xu-dong YANG Jun-shan |
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| Institution: | Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China |
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| Abstract: | OBJECTIVE To study the water-soluble constituents of Clerodendranthus spicatus.METHODS Various column chromatographic techniques were used to isolate the constituents, and their structures were identified by comparing their spectral data with those in literature. RESULTS Fifteen compounds were isolated and elucidated as caffeic acid(1), caffeic acid methyl ester(2), caffeic acid ethyl ester(3), danshensu(4), ethyl 3, 4-dihydroxyphenyllactate(5), rosmarinic acid(6), methyl rosmarinate(7), ethyl rosmarinate(8), isorinic acid(9), dihydroconiferyl alcohol(10), dihydrosinapyl alcohol(11), salvianolic acid C(12), salvianolic acid H(13), 3′-O-(8″-Z-caffeoyl)rosmarinic acid methyl ester(14) and baicalein(15). CONCLUSION Compounds 2, 4-5 and 9-15 are obtained from this species for the first time. |
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| Keywords: | Lamiaceae Clerodendranthus spicatus(Thunb Clerodendranthus spicatus(Thunb" target="_blank">)')" href="#">Clerodendranthus spicatus(Thunb ) dihydroconiferyl alcohol dihydrosinapyl alcohol salvianolic acid C salvianolic acid H |
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