| Cr(Ⅵ)化合物引起DNA损伤的机制 |
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| 引用本文： | 王晓峰,徐立红.Cr(Ⅵ)化合物引起DNA损伤的机制[J].环境与健康杂志,2006,23(1):93-96. |
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| 作者姓名： | 王晓峰 徐立红 |
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| 作者单位： | 1. 浙江大学医学院生物化学与分子生物学教研室,浙江,杭州,310031
2. 浙江大学劳动卫生与环境卫生研究所,浙江,杭州,310031 |
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| 摘 要： | 六价铬Cr(Ⅵ)]是一种公认的环境化学毒物,可导致多种类型的DNA损伤.但其本身并不能直接作用于DNA,它以氧阴离子形式通过非专一性的磷酸/硫酸阴离子通道透过细胞膜后经细胞内的还原剂还原形成一系列低价态铬,如五价铬Cr(Ⅴ)]、四价铬Cr(Ⅳ)]和三价铬Cr(Ⅲ)].该文主要对Cr(Ⅵ)化合物进入体内后如何引起DNA损伤及DNA损伤类型作一概述.
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| 关 键 词： | 铬 DNA损伤 自由基 碱基氧化 |
| 文章编号： | 1001-5914(2006)01-0093-04 |
| 收稿时间： | 2005-10-20 |
| 修稿时间： | 2005年10月20 |
Mechanisms of DNA Damage Induced by Hexavalent Chromium Compounds |
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| WANG Xiao-feng,XU Li-hong.Mechanisms of DNA Damage Induced by Hexavalent Chromium Compounds[J].Journal of Environment and Health,2006,23(1):93-96. |
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| Authors: | WANG Xiao-feng XU Li-hong |
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| Institution: | Department of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310031, China |
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| Abstract: | Hexavalent chromiumCr(VI)] is a well-know environmental toxicant which can cause many types of DNA damage. However Cr(VI) does not react directly with DNA itself, it penetrates the cell membrane through the nonspecific phosphate/sulphate anion channel and undergoes a reductive metabolism to a series of lower oxidation state including quinquevalent chromiumCr(V)], quadrivalent chromiumCr(IV)] and trivalent chromiumCr(III)]. Cr(III) can form variety of Cr-DNA adducts; moreover oxidative Cr(V) and free radicals generated during the reduction cause DNA oxidative damage. The process of how Cr(VI) induce DNA damage after entered the cells and types of DNA lesions were briefly reviewed in the present article. |
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| Keywords: | Chromium DNA Damage Free radicals Base oxidation |
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