Contribution of increased minimal coronary resistance and attenuated vascular adaptive remodeling to myocardial ischemia in patients with systemic hypertension and ventricular hypertrophy |
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| Authors: | Kataoka Tetsuro Hamasaki Shuichi Ishida Sanemasa Saihara Keishi Okui Hideki Fukudome Tsuyoshi Shinsato Takurou Mizoguchi Etsuko Ninomiya Yuichi Otsuji Yutaka Minagoe Shinichi Tei Chuwa |
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| Institution: | First Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan. |
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| Abstract: | This study assessed the impact of coronary vascular adaptive remodeling and coronary vascular reactivity on myocardial ischemia in patients with hypertension and left ventricular hypertrophy. Myocardial ischemia is associated with impaired endothelium-independent vasodilation of resistance coronary arteries and increased minimal coronary resistance. These changes may occur in association with lumen reduction caused by attenuated adaptive remodeling in response to plaque accumulation. |
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