Effects of lidocaine and verapamil on early afterdepolarizations in isolated rabbit sinoatrial node |
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| Authors: | Shun-ichi Miyamae Tomio Matsuda Kashima Goto Hidemaro Mori |
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| Affiliation: | (1) Department of Physiology, Kanazawa Medical University, Uchinada, Ishikawa, Japan;(2) Department of Anesthesiology, Kanazawa Medical University, Uchinada, Ishikawa, Japan;(3) Department of Physiology, Kanazawa Medical University, Uchinada, Ishikawa, 920-02, Japan |
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| Abstract: | The effects of local anaesthetic anti-arrhythmic agents (lidocaine) and Ca antagonists (Verapamil) have been examined on the early afterdepolarizations (EADs) in isolated rabbit sinoatrial (SA) node. In a nominally calcium free and magnesium free solution, strontium (0.5–4.5 mM) produced an EAD in small pieces isolated from the SA node. The additional presence of 0.02–0.6mM lidocaine did not abolish the strontium (0.5mM)-induced EAD. 0.6mM lidocaine produced an increase in EAD amplitude and then abolished a prolonged action potential (AP) associated with repetitive EADs. On the other hand, the addition of 4µM verapamil abolished the strontium (0.5mM)-induced EAD but did not abolish the AP.It is concluded that under conditions when the AP is not abolished, EAD blockade by lidocaine is less effective than that by verapamil.(Miyamae S, Matsuda T, Goto K, et al.: Effects of lidocaine and verapamil on early afterdepolarizations in isolated rabbit sinoatrial node. J Anesth 5: 213–220, 1991) |
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| Keywords: | Isolated sinoatrial node preparation Strontium Early afterdepolarization Lidocaine Verapamil |
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