Guidelines for safety management of granulocyte transfusion in Japan |
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Authors: | Akimichi Ohsaka Atsushi Kikuta Hitoshi Ohto Akira Ohara Akaru Ishida Koji Osada Tetsunori Tasaki Akira Kamitamari Asayuki Iwai Shunro Kai Taira Maekawa Yasutaka Hoshi |
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Institution: | 1. Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan 2. Department of Pediatrics, Fukushima Medical University, Fukushima, Japan 3. Division of Blood Transfusion and Transplantation Immunology, Fukushima Medical University, Fukushima, Japan 4. Division of Transfusion Medicine, Toho University Omori Medical Center, Tokyo, Japan 5. Department of Internal Medicine, Tachikawa Hospital, Federation of National Public Service Personnel Mutual Aid Associations, Tokyo, Japan 6. Blood Transfusion Service, Tokyo Jikei University Hospital, Tokyo, Japan 7. Department of Pediatrics, Sasebo City General Hospital, Nagasaki, Japan 8. Department of Pediatrics, Iwakuni Children’s Hospital, Kochi, Japan 9. Department of Transfusion Medicine, Hyogo College of Medicine, Nishinomiya, Japan 10. Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan
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Abstract: | Granulocyte transfusion (GTX) has recently been revived by the ability to stimulate granulocyte donors with granulocyte colony-stimulating factor (G-CSF), resulting in a greatly increased number of cells that can be collected. However, there is a paucity of guidelines for assessing the appropriateness and safety management of GTX. The objective of this study was to establish guidelines for the safety management of GTX appropriate for the clinical situation in Japan. The Japan Society of Transfusion Medicine and Cell Therapy, Granulocyte Transfusion Task Force issued the first version of guidelines for GTX considering the safety management of both granulocyte donors and patients who receive GTX therapy. The current guidelines cover issues concerning: (1) the appropriateness of medical institutions, (2) management of granulocyte donors, (3) quality assurance of granulocyte concentrates, (4) administration of granulocyte concentrates, (5) evaluation of the effectiveness of GTX therapy, and (6) complications of GTX therapy. The simple ‘bag separation method’ without apheresis may be recommended for granulocyte collection in pediatric patients. The first version of guidelines for GTX therapy has been established, which may be appropriate for the clinical situation in Japan. Care should be taken to perform the safety management of both granulocyte donors and patients who receive GTX therapy. |
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