部分液体通气治疗急性肺损伤家兔

目的 观察部分液体通气（ＰＬＶ）对急性肺损伤（ＡＬＩ）家兔肺内气体交换、肺顺应性、体循环功能的影响。方法 健康雄性新西兰兔２４只，用油酸制备成急性肺损伤模型后随机分为３组，每组８只。各组采用不同方法治疗：呼气末正压（ＰＥＥＰ）组，常规机构通气（ＣＭＶ）＋ＰＥＥＰ治疗；生理盐水（ＮＳ）组，肺内注入ＮＳ同时＋ＣＭＶ＋ＰＥＥＰ；ＰＤＣ组，肺内注入全氟碳化合物－全氟萘烷（ＦＤＣ）同时＋ＣＭＶ＋ＰＥＥＰ。分

Experimental study of partial liquid ventilation in rabbits with acute lung injury

OBJECTIVE: To observe the effectiveness of partial liquid ventilation (PLV) on gas exchange, pulmonary compliance (Cst), blood dynamics in the oleic acid (OA) induced acute lung injury (ALI) rabbits. METHODS: 24 healthy male New Zealand rabbits were randomly allocated to three groups and treated with various methods after OA acute lung injury model established. The study groups as follows: PEEP group with conventional mechanical ventilation (CMV) and PEEP, normal saline (NS) group with CMV, PEEP and NS, FDC group with CMV, PEEP and FDC. The parameters such as blood gases, Cst, circulation state were observed before and after treatment. RESULTS: In FDC group, PaO2 increased from (90 +/- 6) mm Hg to (232 +/- 26) mm Hg(P < 0.05), PaCO2 decreased from (52.1 +/- 2.8) mm Hg to (40.1 +/- 3.0) mm Hg (P < 0.05), Cst increased from (1.05 +/- 0.11) ml/cm H2O to (1.79 +/- 0.24) ml/cm H2O(P < 0.05). HR, MAP and CVP showed no significant changes after treatment compared with pretreatment values in FDC group. CONCLUSION: Pulmonary gas exchange and pulmonary compliance improved significantly during PLV in the ALI rabbits, without obvious influence on hemodynamic status.