The effects of prostaglandins E1, E2, F1α and F2α on guinea-pig ileal and colonic peristalsis

Prostaglandins (PGE₁, E₂, F_1α and F_2α) have been tested on the peristaltic reflex in isolated segments of guinea-pig ileum and colon using simultaneous recordings of fluid propulsion and longitudinal and circular muscle activity. Propulsion and circular muscle peristaltic activity were increased by serosally applied PGF compounds in the ileum and PGE or PGF compounds in the colon following initial contraction of the longitudinal muscle. This is consistent with a role for prostaglandins in peristalsis. Mucosally applied PGF compounds had no significant effect.