Columnar deformation of human red blood cell by highly localized fiber optic Bessel beam stretcher |
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| Authors: | Sungrae Lee Boram Joo Pyo Jin Jeon Seongil Im Kyunghwan Oh |
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| Affiliation: | 1.Photonic Device Physics Laboratory, Department of physics, Yonsei University, Seoul 120-749, South Korea;2.Electron Device Laboratory, Department of physics, Yonsei University, Seoul 120-749, South Korea |
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| Abstract: | A single human red blood cell was optically stretched along two counter-propagating fiber-optic Bessel-like beams in an integrated lab-on-a-chip structure. The beam enabled highly localized stretching of RBC, and it induced a nonlinear mechanical deformation to finally reach an irreversible columnar shape that has not been reported. We characterized and systematically quantified this optically induced mechanical deformation by the geometrical aspect ratio of stretched RBC and the irreversible stretching time. The proposed RBC mechanism can realize a versatile and compact opto-mechanical platform for optical diagnosis of biological substances in the single cell level.OCIS codes: (350.4855) Optical tweezers or optical manipulation, (060.2310) Fiber optics, (060.2370) Fiber optics sensors, (130.3990) Micro-optical devices |
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