| 大鼠大脑中动脉原弹性蛋白mRNA表达的增龄变化 |
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| 引用本文： | 文灿,朱星红,孙建森,糜建红,宋林. 大鼠大脑中动脉原弹性蛋白mRNA表达的增龄变化[J]. 解剖学杂志, 2002, 25(5): 447-450 |
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| 作者姓名： | 文灿 朱星红 孙建森 糜建红 宋林 |
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| 作者单位： | 第三军医大学解剖学教研室,重庆,400038 |
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| 摘 要： | 目的 :检测各年龄组大鼠大脑中动脉原弹性蛋白mRNA表达的变化。方法 :原位杂交染色 ,常规光镜观察 ,图像分析 :结果 :大鼠大脑中动脉的内膜、中膜和外膜均有原弹性蛋白mRNA的表达 ,随年龄增加 ,表达显著减弱。结论 :原弹性蛋白mRNA表达减弱可能是弹性纤维含量随增龄而减少的主要原因之一 ,与老年性脑血管疾病关系密切。
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| 关 键 词： | 脑动脉 大脑中动脉 原弹性蛋白 大鼠 |
Aging changes of tropoelastin mRNA expression in middle cerebral artery in rats |
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| WEN Can,ZHU Xing Hong,SUN Jian Sen,MI Jian Hong,SONG Lin. Aging changes of tropoelastin mRNA expression in middle cerebral artery in rats[J]. Chinese Journal of Anatomy, 2002, 25(5): 447-450 |
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| Authors: | WEN Can ZHU Xing Hong SUN Jian Sen MI Jian Hong SONG Lin |
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| Abstract: | Objective:To study the changes of tropoelastin mRNA expression in middle cerebral artery (MCA) in rats of different ages. Methods:In situ hybridization and image analysis were used. Results:Tropoelastin mRNA expression was found in intima,media and adventitia of the MCA,and the expression decreased with the increase of age. Conclusion:The decrease of tropoelastin mRNA may be one of the important reasons for the decrease of the elasic fiber content,and it is related with the cerebrovascular disease in the aged. |
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| Keywords: | cerebral arteries middle cerebral artery tropoelastin rats |
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