| 高寒菊科植物提取物中α-葡萄糖苷酶抑制剂的筛选 |
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| 引用本文： | 黄元, 陈睿, 马继雄, 陈振宁, 曾阳. 高寒菊科植物提取物中α-葡萄糖苷酶抑制剂的筛选[J]. 中国药科大学学报, 2008, 39(6): 566-569. |
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| 作者姓名： | 黄元 陈睿 马继雄 陈振宁 曾阳 |
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| 作者单位： | 1.青海师范大学生命与地理科学学院 |
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| 基金项目： | 青海省科技厅资助项目 |
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| 摘 要： | 目的:从高寒菊科植物中筛选α-葡萄糖苷酶抑制剂。方法:采用α-葡萄糖苷酶活性测定方法,对37种经水提取的高寒菊科植物进行了α-葡萄糖苷酶抑制活性的筛选。结果:在样品浓度0.625mg/mL反应体系下,5种高寒菊科植物水提取物显著抑制α-葡萄糖苷酶活性,抑制率达到50%上。结论:α-葡萄糖苷酶活性测定结果显示,某些高寒菊科植物提取物能显著抑制α-葡萄糖苷酶活性,如果对其进一步的分离、纯化并提取活性部位,有望获得高活性的α-葡萄糖苷酶抑制剂。
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| 关 键 词： | 高寒菊科植物提取物 α-葡萄糖苷酶抑制剂 活性筛选 |
Screening of alpha-glucosidase inhibitors from the alpine Compositae herb extracts |
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| HUANG Yuan,CHEN Rui,MA Ji-xiong,CHEN Zhen-ning,ZENG Yang. Screening of alpha-glucosidase inhibitors from the alpine Compositae herb extracts[J]. Journal of China Pharmaceutical University, 2008, 39(6): 566-569 |
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| Authors: | HUANG Yuan CHEN Rui MA Ji-xiong CHEN Zhen-ning ZENG Yang |
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| Affiliation: | HUANG Yuan,CHEN Rui,MA Ji-xiong,CHEN Zhen-ning,ZENG Yang College of Life , Geographical Sciences,Qinghai Normal University,Xining 810008,China |
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| Abstract: | Aim:To screen alpha-glucosidase inhibitors from alpine Compositae herbs(ACH).Methods:By determining alpha-glucosidase enzyme activity,37 kinds of ACH water extracts were tested in search of alpha-glucosidase inhibitors.Results:It was found that 5 kinds of ACH water extracts at the concentraction of 0.625 mg/mL inhibited alpha-glucosidase and that their inhibitory rates were above 50%.Conclusion:It was indicated that the extracts of ACH had inhibitory activities on alpha-glucosidase.Therefore,ACH is suggeste... |
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| Keywords: | alpine Compositae herbs extract alpha-glucosidase inhibitor activity screening |
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