曲美他嗪和辅酶Q10治疗稳定性劳力型心绞痛的对比研究

目的:对比研究曲美他嗪和辅酶Q10治疗稳定性心绞痛的疗效。方法:选择108例稳定性劳力型心绞痛,随机分成曲美他嗪组54例,辅酶Q10组54例,两组常规治疗(阿司匹林联合单一的硝酸酯制剂或β阻滞剂或钙通道阻滞剂)相同,曲美他嗪组给予曲美他嗪20mg,每天三次口服,辅酶Q10组给予辅酶Q1020mg,每天三次口服,疗程均为12周。观察临床疗效指标改善情况。结果:曲美他嗪组心绞痛及心电图改善分别为94.4%和68.5%,辅酶Q10组分别为88.9%和59.3%。组间比较差异有显著意义(P<0.05)。结论:曲美他嗪治疗稳定性劳力型心绞痛的疗效优于辅酶Q10。

Contrast study of trimetazidine and coenzyme Q10 for stable exertional angina

Objective: To compare the effect of trimetazidine and coenzyme Q10 for treatment of patients with stable exertional angina.Methods: 108 patients with stable exertional angina were randomly divided into trimetazidine group (n=54) and coenzyme Q10 group(n=54).Two group were combined with any one of nitrates,β blockers and calcium antagonists to aspirin.The trimetazidine group were given trimetazidine 20 mg,po,tid for 12 weeks While the coenzyme Q10 group were received coenzyme Q10 20 mg,po tid for 12 weeks.Clinical treatment effective indexes were observed.Results: Total efficacy rates in relieving angina symptom and improving the ECG parameters of the trimetazidine group were 94.4% and 68.5%, respectivealy.The same parameters of coenzyme Q10 group were 88.9% and 59.3% respetively.The above parameters of trimetazidine group were remarkably better than coenzyme Q10 group (P<0.05).Conclusion: The efficacies of trimetazidine are better than coenzyme Q10 for stable exertional angina.