Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors |
| |
| Authors: | H. Friess P. Berberat M. Schilling J. Kunz M. W. Büchler M. Korc |
| |
| Affiliation: | (1) Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, CH-3010 Berne, Switzerland;(2) Departments of Medicine and Biological Chemistry, Division of Endocrinology and Metabolism, University of California, Irvine, Calif., USA |
| |
| Abstract: | Molecular alterations play a key role in the pathogenesis of gastrointestinal cancers. In the present paper we describe relevant molecular alterations in human pancreatic adenocarcinomas. Overexpression of growth factor receptors (EGF receptor, c-erbB2, c-erbB3, TGF receptor I–III), growth factors (EGF, TGF , TGF-1-3, aFGF, bFGF), adhesion molecules (ICAM-1, ELAM-1) and gene mutations (p53, K-ras, DCC, APC) are present in a significant number of these tumors. These changes stimulate tumor growth and enhance the metastatic behavior of pancreatic cancer cells and thereby may contribute to shorter postoperative survival following tumor resection.Abbreviations EGF Epidermal growth factor - ELAM Endothelial leukocyte adhesion molecule - aFGF Acidic fibroblast growth factor - bFGF Basic fibroblast growth factor - HER Human EGF-receptor - ICAM Intercellular adhesion molecule - TGF Transforming growth factor |
| |
| Keywords: | Pancreatic cancer Growth factor receptors Growth factors Adhesion molecules Gene mutations |
| 本文献已被 SpringerLink 等数据库收录！ |
|
