In Vitro Induction of Specific T Cells Able to Help in the Generation of Delayed-Type Hypersensitivity by Thymus-Dependent and Type-II 'Thymus-Independent' Antigens |
| |
| Authors: | P. A. BRETSCHER |
| |
| Affiliation: | Departments of Immunology and Medicine, University of Alberta, Edmonton, Alberta, Canada |
| |
| Abstract: | An in vitro system is described which supports the primary induction of T cells able to help in the induction of delayed-type hypersensitivity. This system is used to demonstrate that hapten-Ficoll conjugates induce potent hapten-specific T cells with this function. These type-II 'thymus-independent' antigens are thus able to induce specific regulatory T cells. These helper T cells are similar to those induced by classical thymus-dependent antigens in that they are specific for antigen rather than idiotype and act by a linked mechanism. |
| |
| Keywords: | |
|
|
