| 趋化因子受体CCR7在骨肉瘤组织中的表达和临床意义 |
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| 引用本文： | 张弘韬,王猛,陈观印,颜世举,马琼,刘云燕,艳华,马保安.趋化因子受体CCR7在骨肉瘤组织中的表达和临床意义[J].现代肿瘤医学,2016(17):2772-2774. |
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| 作者姓名： | 张弘韬 王猛 陈观印 颜世举 马琼 刘云燕 艳华 马保安 |
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| 作者单位： | 第四军医大学唐都医院骨科·全军骨科中心暨骨肿瘤研究所，陕西 西安 710038 |
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| 基金项目： | 国家自然科学基金(编号81201633) |
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| 摘 要： | 目的：研究 CCR7在人骨肉瘤组织中的表达情况，并探讨 CCR7表达与临床病理之间的关系。方法：收集临床50例骨肉瘤组织及20例骨软骨瘤组织，使用免疫组织化学方法检测其 CCR7的表达水平。结果：CCR7在骨肉瘤组织和骨软骨瘤组织中的阳性表达率分别为80．00％和15．00％。CCR7阳性表达和骨肉瘤肿瘤大小及转移密切相关（P ＜0．05），而与年龄、性别、临床分期及组织学分型没有明显关系（P ＞0．05）。结论：骨肉瘤组织中 CCR7高表达预示着其在肿瘤增长和肿瘤转移可能起到一定的作用。因此 CCR7可能会成为临床上治疗骨肉瘤一个新的靶点。
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| 关 键 词： | 趋化因子受体7 骨肉瘤 增殖 转移 |
Expression of CCR7 in osteosarcoma and its clinical significance |
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| Abstract: | Objective:To investigate the expression of CCR7 in osteosarcoma and discuss the underlying relation-ship between the expression and clinical significance.Methods:Immunohistochemical staining was used to measure the expression of CCR7 in 50 cases of osteosarcoma tissues and 20 cases of osteochondroma tissues.Results:The posi-tive expression rates of CCR7 were 80.00% and 15.00% respectively in 50 cases of osteosarcoma tissues and 20 ca-ses of osteochondroma tissues.The CCR7 expression were related to the size of the tumor(P <0.05)and the metasta-sis of osteosarcoma(P <0.05).There was no evident link between CCR7 expression and age,gender,clinical stages and histological type(P >0.05).Conclusion:The highly expressed CCR7 in osteosacroma indicates that CCR7 may play a significant role in tumor progression and metastasis.Therefore,CCR7 could be an ideal target for the treatment of osteosarcoma. |
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| Keywords: | CCR7 osteosarcoma proliferation metastasis |
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