微波深部热疗加同步放化疗治疗中晚期宫颈癌的临床效果

目的:评价微波深部热疗在中晚期巨块型宫颈癌治疗中的疗效及安全性。方法:将经放化疗和放化热疗治疗的100例Ⅱb-Ⅲb期、肿瘤直径大于4cm的巨块型宫颈癌患者各50例，分为对照组和实验组。对照组放化疗:外照射均采用6MV-X加速器调强放射治疗+192铱高剂量率后装腔内照射，同步顺铂40mg/m2，静点，每周1次，与外照射同步结束。实验组:放化疗与对照组相同，另加局部体外热疗，温度为(40±1)℃，60分/次，2次/周，共10次。治疗结束后1个月复查相关检查，进行疗效评价。结果:实验组达到CR者92%(46/50)，对照组达到CR者仅78%(39/50)，肿瘤缩小率实验组明显高于对照组，差异有统计学意义(χ2=4.201， P＜0.039)。结论:深部热疗联合同步放化疗是治疗中晚期宫颈癌、特别是巨块型宫颈癌的一种安全有效的方法，具有临床推广价值。

Clinical study of microwave hyperthermia plus radiotherapy and chemotherapy in the treatment of advanced cervical cancer

Objective:To evaluate the safety and efficacy of microwave hyperthermia in the treatment for advanced bulky cervical carcinoma.Methods:All 100 cases of cervical cancer patients with IIb-IIIb stage,tumor diameter greater than 4cm were treated by radiotherapy and chemotherapy,and were divided into control group and experimental group.Radiotherapy in control group:6MV accelerator IMRT treatment+192 iridium in high dose rate intracavitary irradiation,concurrent cisplatin 40mg/m2 intravenous,once a week,and external irradiation synchronization terminates.In the experimental group,the temperature was (40±1)℃,60 points/second,2 times/week.1 month after the end of treatment to review the relevant examination.Results:In the experimental group,92%(46/50) of CR was achieved,and the control group was only 78%(39/50).The tumor shrinkage rate was significantly higher than that in the control group (P＜0.039).Conclusion:Deep hyperthermia combined with radiotherapy and chemotherapy is a safe and effective method for the treatment of advanced cervical cancer,especially the giant cervical carcinoma.