业余时间体育活动与膀胱癌发生风险关系的荟萃分析

目的:探索业余时间体育活动和膀胱癌风险的关系。方法:系统检索2014年3月10前发表在PubMed、Embase、Cochrane Library、Web of Science、CNKI和万方数据库上关于业余时间体育活动与膀胱癌关系的文献。采用随机效应模型对合并相对危险度(RR)及其95%可信区间(CI)进行定量计算。结果:共10篇文献合计1 216 067名参与者和4 865例膀胱癌病例纳入本分析中。与不经常在业余时间进行体育锻炼的人相比，经常在闲暇时间进行体育活动的人患膀胱癌的风险降低20%(RR=0.8，95%CI:0.64~0.99)，进一步偏倚分析提示不存在发表偏倚。结论:业余时间体育活动对膀胱癌有预防保护作用。

Leisure-time exercise and risk of bladder cancer :A Meta-analysis

Objective:To determine the association between leisure-time exercise and bladder cancer risk.Methods:We systematically searched databases of PubMed，Embase，Cochrane Library，Web of Science，CNKI and Wan Fang from their inception through March 10th，2014 for articles that evaluated the association between leisure-time exercise and risk of bladder cancer.Random effects models were used to calculate the summary estimates for relative risks（RRs）and their corresponding 95% confidence intervals（CIs).Results:Ten studies involving a total of 1 216 067 participants and 4 865 bladder cancer cases were included in this analysis.Meta-analysis of all included studies showed that the risk of bladder cancer among the most physically active people was decreased about 20% compared with the least active people（RR=0.8，95%CI:0.64~0.99).No evidence of publication bias was observed from the visual inspection of the funnel plot and Begg's test.Conclusion:Our findings provide support for a protective effect of leisure-time exercise on bladder cancer.