75岁以上老年食管癌适形放疗疗效分析

目的:探讨三维适形放疗对75岁以上老年食管癌患者的疗效及毒副反应。方法:回顾性分析我院自2009年1月至2012年7月接受根治性三维适形放疗（three-dimensional conformal radiotherapy，3DCRT）和常规分割放疗（conventional fraction radiotherapy，CFRT）的112例75岁以上老年食管鳞癌患者临床资料，对比分析两组近期有效率,1、2年局部控制率及生存率，毒副反应。结果:3DCRT组、CFRT组近期有效率分别为86.5%和68.8%，1年局部控制率分别为76.1%和53.3%。2年局部控制率分别为46.3%和24.4%，1年生存率分别为79.1%和64.4%，2年生存率分别为49.3%和28.9%。治疗毒副反应相似。结论:75岁以上老年食管癌患者行三维适形放疗疗效优于常规分割放疗，不良反应可耐受。

Efficacy of three - dimensional conformal radiotherapy(3DCRT)in patients over 75 years old with esophageal carcinoma

Objective:To analyze the efficacy and the toxicity of esophageal carcinoma treated with three - dimen-sional conformal radiotherapy. Methods:From January 2009 to June 2012,112 patients over 75 years old with esopha-geal carcinoma treated with three - dimensional conformal radiotherapy(3DCRT)and conventional fraction radiothera-py(CFRT)were retrospectively analyzed. The short - term effects,acute side radioative effects,1,2 - year local con-trol rates and the survival rates were evaluated. Results:The short - term effects of 3DCRT and CFRT were 88. 0%and 73. 4% . The 1 - year local control rates were70. 1% and 56. 7% ,the 2 - year local control rates were 32. 8%and 25. 4% . The 1 - year overall survival rates were 58 . 2 % and 44 . 8 % ,the 2 - year overall survival rates were 35. 8% and 25. 3% . The acute side radioative effects in the two groups were similar. Conclusion:For patients o-ver 75 years old with esophageal carcinoma,the efficacy of three - dimensional conformal radiotherapy is superior to conventional fraction radiotherapy and the toxicities can be tolerated.