血清白蛋白检测对胰腺癌高剂量少分次放疗的预后评估

目的:评估血清白蛋白检测在预测胰腺癌高剂量少分次放疗预后的价值.方法:收集未经治疗的胰腺癌Ⅲ期患者,采用螺旋断层放疗设备治疗,按照高剂量少分次放疗剂量模式,放疗前行血清白蛋白检测.通过随访获取患者生存时间,评估生存时间采用Kaplan-Meier法,生存差异的比较采用Log-rank检验,相关分析采用Spearman相关分析法.结果:97例患者中位总生存时间12个月.血清白蛋白高值组中位生存时间15个月,低值组中位生存时间9个月,生存分析显示血清白蛋白水平与总生存时间在统计学上有关(P=0.007),放疗前血清白蛋白水平与放疗前减黄(r=-0.24,P=0.018)呈负相关,与肿瘤部位(r=0.279,P=0.006)呈正相关.结论:胰腺癌高剂量少分次放疗前血清白蛋白检测在预测患者总生存时间方面具有重要价值.

Prognostic value of serum albumin in pancreatic cancer treated by hypofraction radio-therapy

Objective:To evaluate the value of serum albumin in predicting prognostic value in patients with pan-creatic adenocarcinoma treated with hypofraction radiotherapy. Methods:Collect the untreated stage Ⅲ pancreatic cancer patients on hypofraction mode with tomotherapy. Check serum albumin before radiotherapy. Get survival time by follow-up the patients. Using Kaplan-Meier method to assess the survival time. Log-rank test was used to com-pare the survival differences. Results:In 97 patients,the median overall survival time was 12 months. The median sur-vival time of the high value group was 15 months,and the low value normal group was 9 months. Kaplan-Meier anal-ysis showed that serum albumin level was significantly associated with the overall survival time(P=0. 007). Serum albumin level before treatment had a negative correlation with jaundice before treatment(r= -0. 24,P=0. 018). Se-rum albumin level had a positive correlation with tumor location(r=0. 279,P=0. 006). Conclusion:Serum albumin before radiation has a significant value in predicting overall survival time of pancreatic cancer treated with hypofraction radiotherapy.